{"id":"W1611980142","doi":"10.1016/j.molmet.2015.09.009","title":"AstroGenesis: And there was leptin on the sixth day","year":2015,"lang":"en","type":"article","venue":"Molecular Metabolism","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Canadian Diabetes Association","keywords":"Leptin; Orexigenic; Leptin receptor; Endocrinology; Internal medicine; Hypothalamus; Energy homeostasis; Biology; Proopiomelanocortin; Arcuate nucleus; Glucose homeostasis; Signal transduction; Neuropeptide Y receptor; Cell biology; Receptor; Medicine; Diabetes mellitus; Neuropeptide; Obesity; Insulin resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003434284,0.0001268243,0.0001268326,0.00003922481,0.0001121183,0.00007991092,0.0002182457,0.00003571248,0.00004073814],"category_scores_gemma":[0.0002995285,0.00008057337,0.00005439071,0.0001514359,0.00009696797,0.00006530063,0.00007758463,0.00009736168,0.0001508469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006537863,"about_ca_system_score_gemma":0.00002570564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009278007,"about_ca_topic_score_gemma":0.000001133969,"domain_scores_codex":[0.998781,0.0002989903,0.0001111709,0.0002784891,0.00034655,0.0001837456],"domain_scores_gemma":[0.9993816,0.00007057084,0.00005037637,0.0003556174,0.00002936774,0.0001124827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003100165,0.00006693437,0.000274919,0.000003373691,0.00001127964,0.00004646979,0.0003971207,0.0001794307,0.821416,0.170841,0.00121191,0.005520666],"study_design_scores_gemma":[0.0002995118,0.00002328611,0.008342429,0.000006076321,0.00001618283,0.00000773719,0.00006332225,0.0001436414,0.8878874,0.002965748,0.1001309,0.0001137587],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879199,0.0006855889,0.0004745223,0.002574352,0.0001419056,0.0001585304,0.00000382429,0.00004392883,0.007997394],"genre_scores_gemma":[0.9964283,0.00003405226,0.0001382993,0.00271656,0.00007417194,0.00001061897,7.671616e-7,0.00001697286,0.0005803194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1678752,"threshold_uncertainty_score":0.3285686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0340531472429775,"score_gpt":0.2468157453614188,"score_spread":0.2127625981184413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}