{"id":"W1612492173","doi":"10.1079/pavsnnr201510012","title":"Epigenetic reprogramming in mammalian cell differentiation, transdifferentiation and dedifferentiation.","year":2015,"lang":"en","type":"article","venue":"CABI Reviews","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Biotechnology and Biological Sciences Research Council","keywords":"Transdifferentiation; Reprogramming; Epigenetics; Biology; Somatic cell; Cellular differentiation; Epigenetic regulation of neurogenesis; Chromatin; Epigenesis; Embryonic stem cell; Cell biology; Cell fate determination; Regenerative medicine; Cell potency; Stem cell; Cell; Genetics; DNA methylation; Chromatin remodeling; Adult stem cell; Gene expression; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004877444,0.0001752917,0.0002301946,0.00007778075,0.00004340558,0.00004573621,0.00009759577,0.0001370101,0.00001276924],"category_scores_gemma":[0.0001341835,0.000163045,0.00007183947,0.0001304275,0.00002983578,0.000007476021,0.00004032836,0.00007897524,0.00001105377],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002350612,"about_ca_system_score_gemma":0.00003105966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001688432,"about_ca_topic_score_gemma":0.00009797177,"domain_scores_codex":[0.9986067,0.0002135738,0.0004543676,0.0003927452,0.0001259545,0.0002066672],"domain_scores_gemma":[0.9993146,0.000008819372,0.0001587407,0.0003072136,0.00007390087,0.0001367078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0000600353,0.0003045234,0.3628567,0.0003827542,0.00002313637,0.000002296076,0.001056155,0.0001023606,0.3794883,0.0001699186,0.0004181468,0.2551357],"study_design_scores_gemma":[0.003192091,0.0005204727,0.6001044,0.0001162671,0.0001244062,0.000004258733,0.0001697295,0.0007392848,0.2267719,0.001592481,0.1657711,0.0008936612],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9341666,0.04523948,0.01939028,0.00006395319,0.0001822576,0.0005317639,0.00000336523,0.000009367244,0.0004129072],"genre_scores_gemma":[0.9897551,0.007829038,0.001461076,0.0000426441,0.0001354144,0.00007773528,0.0002555798,0.00002142908,0.0004219918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.254242,"threshold_uncertainty_score":0.6648784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03241950732245988,"score_gpt":0.2729386027953667,"score_spread":0.2405190954729069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}