{"id":"W1614901871","doi":"10.4049/jimmunol.171.5.2427","title":"TCR Binding Kinetics Measured with MHC Class I Tetramers Reveal a Positive Selecting Peptide with Relatively High Affinity for TCR","year":2003,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"National Institute of General Medical Sciences; National Institute of Mental Health; Emory University; National Institutes of Health; Cancer Research Institute","keywords":"T-cell receptor; Avidity; Agonist; Major histocompatibility complex; Tetramer; Negative selection; Biology; Receptor–ligand kinetics; Peptide; Kinetics; Chemistry; Biophysics; T cell; Cell biology; Antigen; Molecular biology; Receptor; Immunology; Biochemistry; Immune system; Gene; Enzyme; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003254833,0.0004241772,0.0004841019,0.0002727091,0.0002596808,0.0005404529,0.0002713054,0.0006347531,0.003936291],"category_scores_gemma":[0.0007075122,0.0003122221,0.0002429823,0.0003530422,0.0002071267,0.0004355586,0.0001753113,0.00124401,0.002327171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003359386,"about_ca_system_score_gemma":0.0001850056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000670989,"about_ca_topic_score_gemma":0.0006110773,"domain_scores_codex":[0.9995259,0.00007150935,0.00002535571,0.00008865472,0.0001588894,0.0001296931],"domain_scores_gemma":[0.9992436,0.0003628506,0.00008153752,0.00007745909,0.0001430762,0.00009146777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005348067,0.00001955521,0.000278695,0.00001851201,0.000003229098,0.00001238373,0.00002042391,0.00005619991,0.9986934,0.00005626668,0.00003162159,0.0007563145],"study_design_scores_gemma":[0.000009380488,0.0002942587,0.007246355,0.000005942347,0.00001406146,0.000241161,0.00004860567,0.002702373,0.9883242,0.0001259937,0.0009760145,0.00001166817],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9694536,0.001818089,0.02371205,0.0001346138,0.00002626074,0.00006277829,0.0005853091,0.0002740778,0.003933366],"genre_scores_gemma":[0.9818634,0.0008381746,0.01029469,0.0001522459,0.00001507354,0.00008696429,0.0007675604,0.0001168327,0.005865012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003936291,"threshold_uncertainty_score":0.01316822,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01465398873239196,"score_gpt":0.2249560010707777,"score_spread":0.2103020123383858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}