{"id":"W1614901871","doi":"10.4049/jimmunol.171.5.2427","title":"TCR Binding Kinetics Measured with MHC Class I Tetramers Reveal a Positive Selecting Peptide with Relatively High Affinity for TCR","year":2003,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"National Institute of General Medical Sciences; National Institute of Mental Health; Emory University; National Institutes of Health; Cancer Research Institute","keywords":"T-cell receptor; Avidity; Agonist; Major histocompatibility complex; Tetramer; Negative selection; Biology; Receptor–ligand kinetics; Peptide; Kinetics; Chemistry; Biophysics; T cell; Cell biology; Antigen; Molecular biology; Receptor; Immunology; Biochemistry; Immune system; Gene; Enzyme; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009702651,0.0002566163,0.0004613641,0.0002337641,0.0004586872,0.00002016582,0.0002378191,0.000245552,0.0001365258],"category_scores_gemma":[0.0005286125,0.0001545577,0.0001157025,0.000282905,0.0003771593,0.0002045288,0.0000222866,0.00122936,0.00003994731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002065072,"about_ca_system_score_gemma":0.0001806756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004431966,"about_ca_topic_score_gemma":0.00002825577,"domain_scores_codex":[0.9978037,0.0009633763,0.000546485,0.0001695831,0.0000740564,0.0004428271],"domain_scores_gemma":[0.9971291,0.0009618471,0.000989443,0.0002056634,0.0006921773,0.0000217817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008961387,0.0001980994,0.00054956,0.000009063255,0.001839343,0.000007976868,0.001755989,0.0001551927,0.9832428,0.0008224581,0.001975669,0.0004825334],"study_design_scores_gemma":[0.008330279,0.01357155,0.008699665,0.0003071095,0.0007835727,0.009439095,0.009825258,0.000003242313,0.9255767,0.0001597038,0.02285582,0.0004480022],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887652,0.001222571,0.004585193,0.0007613468,0.001789599,0.0003680857,0.000005681323,0.0000297405,0.002472598],"genre_scores_gemma":[0.9947475,0.00008468496,0.0008745255,0.0001770627,0.00003773263,0.000007473787,0.00001412585,0.00003598277,0.004020963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05766603,"threshold_uncertainty_score":0.630268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01465398873239196,"score_gpt":0.2249560010707777,"score_spread":0.2103020123383858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}