{"id":"W1614911129","doi":"10.1007/978-0-387-73657-0_46","title":"Novel reactive site loop derived mini-serpin inhibitors of recombinant Proprotein Convertase 4","year":2009,"lang":"en","type":"article","venue":"Advances in experimental medicine and biology","topic":"Glycogen Storage Diseases and Myoclonus","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"","keywords":"Serpin; Proprotein convertase; Recombinant DNA; Chemistry; Loop (graph theory); Proprotein Convertases; Biochemistry; Lipoprotein; Mathematics; LDL receptor; Cholesterol; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008869282,0.0001852695,0.0005073635,0.0001297708,0.00002899495,0.000001255292,0.00005082508,0.00009513272,0.00004945431],"category_scores_gemma":[0.00008884183,0.0001278087,0.00004727959,0.0001253513,0.0003805938,0.00009797644,0.00002891863,0.0001198714,0.000002041586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003880512,"about_ca_system_score_gemma":0.00003412503,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002452667,"about_ca_topic_score_gemma":0.00001502611,"domain_scores_codex":[0.9989446,0.00003077245,0.0003733489,0.000329237,0.00008674711,0.0002352907],"domain_scores_gemma":[0.9994699,0.00004731336,0.0001420063,0.0001566933,0.00004748549,0.0001366377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001200294,0.000587469,0.004106526,0.00003919471,0.00001704041,0.0001820007,0.0008145263,1.607638e-7,0.9718259,0.0002631735,0.00006221023,0.0209015],"study_design_scores_gemma":[0.01109207,0.01257819,0.00530408,0.0007576626,0.00007744132,0.0005715453,0.005707871,0.00004158846,0.9535486,0.0003219339,0.00968645,0.0003125935],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9649254,0.03276638,0.00003367212,0.0008752326,0.0003374172,0.0005356359,0.000007372549,0.00001625873,0.0005026239],"genre_scores_gemma":[0.9969662,0.001094069,0.0006613272,0.0009954876,0.0001105045,0.00003151132,0.00007387574,0.000008380326,0.00005866499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03204077,"threshold_uncertainty_score":0.5211889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02275930318838202,"score_gpt":0.3387038580914931,"score_spread":0.3159445549031111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}