{"id":"W1615221424","doi":"10.1161/circ.130.suppl_2.12676","title":"Abstract 12676: C-Terminal Residues of Phospholamban are Critical Determinants of the Quaternary Structure and Function of the Calcium ATPase Regulatory Complex","year":2014,"lang":"en","type":"article","venue":"Circulation","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Phospholamban; SERCA; Biochemistry; Biophysics; Chemistry; Cell biology; ATPase; Förster resonance energy transfer; Calcium ATPase; Transmembrane domain; Protein structure; Biology; Endoplasmic reticulum; Membrane; Enzyme; Fluorescence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002248797,0.0006041051,0.000321918,0.0001263951,0.0002768217,0.000387869,0.0003950224,0.0009011436,0.006461227],"category_scores_gemma":[0.0002239214,0.0001729735,0.0002052128,0.0001216236,0.0005680933,0.000244995,0.0002680271,0.0007153967,0.001938582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004203259,"about_ca_system_score_gemma":0.0002578825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003679551,"about_ca_topic_score_gemma":0.0003128624,"domain_scores_codex":[0.9998384,0.00002986621,0.00001826847,0.00004768276,0.00004832131,0.00001755466],"domain_scores_gemma":[0.9997944,0.00004329698,0.00007966024,0.00001391596,0.00001774869,0.00005105348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004428955,0.00003369296,0.0002722469,0.00008588026,0.000005139059,0.0002526842,0.00001185177,0.0001161825,0.9971373,0.0002030576,0.0001940842,0.00124499],"study_design_scores_gemma":[0.00009446585,0.0002884467,0.005160032,0.00001651194,0.00002155335,0.001391917,0.00002321921,0.001258978,0.9851989,0.0001864166,0.006352219,0.000007419466],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874185,0.002261716,0.004465239,0.001082381,0.0001569869,0.0000722306,0.001023496,0.0001395016,0.003379751],"genre_scores_gemma":[0.985127,0.001188557,0.005297119,0.000316632,0.000088238,0.00006056735,0.001350192,0.00006214491,0.006509475],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006461227,"threshold_uncertainty_score":0.02161497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0185427209978129,"score_gpt":0.2738565773230411,"score_spread":0.2553138563252282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}