{"id":"W1618025150","doi":"10.1111/j.1749-6632.2010.05883.x","title":"What lies ahead for the proprotein convertases?","year":2011,"lang":"en","type":"review","venue":"Annals of the New York Academy of Sciences","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Proprotein Convertases; Furin; Cell biology; Biology; Proteolysis; Receptor; Endosome; Golgi apparatus; Proprotein convertase; Internalization; Chemistry; LDL receptor; Biochemistry; Lipoprotein; Endoplasmic reticulum; Cholesterol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007474112,0.00020098,0.0004843733,0.00003838734,0.0001600421,0.0000270834,0.001302127,0.000305037,0.00001683452],"category_scores_gemma":[0.00005199567,0.00009577283,0.0006035239,0.0001952721,0.0008564332,0.00001157734,0.00008692773,0.0001422883,0.000001827313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000148348,"about_ca_system_score_gemma":0.0002044688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004280475,"about_ca_topic_score_gemma":0.000007271484,"domain_scores_codex":[0.9987935,0.0000585591,0.0004145481,0.0003062043,0.0002126996,0.0002144316],"domain_scores_gemma":[0.9991402,0.00005096518,0.0005436837,0.0001833934,0.00003813358,0.0000436226],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006965146,0.00006258646,0.00001250454,0.005222072,0.000392008,6.186432e-8,0.0002572119,0.000005803339,0.005019718,0.00287638,0.01309957,0.9729824],"study_design_scores_gemma":[0.00005076598,0.0001287708,0.000007334711,0.001285676,0.0002481808,0.000002402546,0.00005663518,0.000001785879,0.0317783,0.0007306634,0.9655873,0.0001221776],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001217636,0.9969477,0.0001135952,0.001590448,0.0001821832,0.0009451829,0.00003131146,0.000002715941,0.00006508941],"genre_scores_gemma":[0.0006079895,0.9972222,0.00008384047,0.0002562343,0.000195526,0.00003860498,0.00004027557,0.00001169338,0.001543605],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9728603,"threshold_uncertainty_score":0.3905503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.162893372229331,"score_gpt":0.3643764516969377,"score_spread":0.2014830794676067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}