{"id":"W1618617054","doi":"","title":"Abstract 19029: The Sirt1 Activator, SRT1720, Attenuates Cardiac Hypertrophy and Fibrosis in a Rodent Pressure Overload Model","year":2014,"lang":"en","type":"article","venue":"Circulation","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"Medicine; Pressure overload; Fibrosis; Muscle hypertrophy; Internal medicine; Cardiac fibrosis; Endocrinology; Cardioprotection; Cardiac function curve; Heart failure; SMAD; Cardiology; Transforming growth factor; Pharmacology; Myocardial infarction; Cardiac hypertrophy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002690968,0.0001427737,0.0002918595,0.00006714736,0.00009809447,0.00004558214,0.00004163239,0.0001213046,0.000006409941],"category_scores_gemma":[0.00006909864,0.0001005194,0.0001448182,0.0001093709,0.00004027933,0.0001321316,0.0000315867,0.0001847964,0.00000574997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004648795,"about_ca_system_score_gemma":0.00003059819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000171988,"about_ca_topic_score_gemma":0.000003874442,"domain_scores_codex":[0.9990014,0.00004109352,0.0002237145,0.0002822436,0.000265395,0.0001861475],"domain_scores_gemma":[0.9994081,0.00008562503,0.00007203676,0.000303858,0.00005896858,0.00007137228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001506689,0.0000770979,0.2563133,0.0002448538,0.0001275735,7.476872e-7,0.00103401,0.1753991,0.5505919,0.0003613844,0.0002348568,0.01546441],"study_design_scores_gemma":[0.0004182999,0.00001343614,0.6882363,0.0001101482,0.0001011545,0.000003089396,0.00004322292,0.3091137,0.001045053,0.0001882095,0.0006287359,0.00009866584],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964354,0.001183402,0.0004350041,0.0005335992,0.0001275683,0.0003702892,0.000009550571,0.00003347092,0.0008717271],"genre_scores_gemma":[0.9992898,0.00009533114,0.0001443282,0.0001312318,0.000234828,0.000017544,0.00002580387,0.0000233339,0.00003778176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5495469,"threshold_uncertainty_score":0.4099061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01458840428409631,"score_gpt":0.2405743396462594,"score_spread":0.2259859353621631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}