{"id":"W1619053513","doi":"10.1001/jamaneurol.2015.1700","title":"Association of Long Runs of Homozygosity With Alzheimer Disease Among African American Individuals","year":2015,"lang":"en","type":"article","venue":"JAMA Neurology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"National Center for Research Resources; National Cancer Institute; National Human Genome Research Institute; National Institute on Aging; Geriatric Research Education and Clinical Center; National Center for Advancing Translational Sciences; Medical Research Council; Department of Pathology, Johns Hopkins University; School of Medicine, Indiana University; University of California, Irvine; National Institute of Mental Health; Feinberg School of Medicine; Perelman School of Medicine, University of Pennsylvania; University of California, Davis; Canadian Institutes of Health Research; University of California, Los Angeles; National Institutes of Health; University of California, San Francisco; Alzheimer Society; University of South Florida; National Alzheimer's Coordinating Center; National Institute on Minority Health and Health Disparities; USF Health Byrd Alzheimer's Institute; Johns Hopkins University; University of Washington; University of Miami; York University; Northwestern University; Cleveland Clinic; Emory University; University of Pennsylvania; Vanderbilt University; Children's Hospital of Philadelphia; Rush University; University of California, San Diego; Office of Research and Development; U.S. Department of Veterans Affairs; Hope Center for Neurological Disorders; Wellcome Trust; University of Southern California; Massachusetts General Hospital; GlaxoSmithKline; National Institute of Neurological Disorders and Stroke; University of Pittsburgh; University of Colorado School of Medicine, Anschutz Medical Campus; Alzheimer's Association","keywords":"Runs of Homozygosity; Genetics; Single-nucleotide polymorphism; Genotype; SNP; Biology; Genome-wide association study; Inbreeding; Population; Allele; Genetic association; Disease; Allele frequency; Locus (genetics); Medicine; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008724066,0.0002884579,0.000269967,0.0008857395,0.0007701346,0.0004384412,0.0002985886,0.0004190393,0.001220035],"category_scores_gemma":[0.003231306,0.000192866,0.0002264374,0.000831829,0.0005140724,0.0002591827,0.0004156945,0.000411173,0.00007389936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001701856,"about_ca_system_score_gemma":0.0002106907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003756484,"about_ca_topic_score_gemma":0.005078341,"domain_scores_codex":[0.9993926,0.0002432683,0.00004348113,0.0001701961,0.00007740151,0.00007301565],"domain_scores_gemma":[0.9984983,0.0004035946,0.0006084027,0.0002072248,0.00012541,0.000157028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001976066,0.00002478555,0.996238,0.00000770789,0.00009859045,0.0002101781,0.0001345358,0.0000557324,0.001362494,0.00006271938,0.00009720033,0.00151043],"study_design_scores_gemma":[0.00001092616,0.00006828553,0.9981958,0.000008069034,0.00007765967,0.000769305,0.0001188475,0.0002814715,0.000223858,0.00008600504,0.0001544995,0.000005251648],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995065,0.0001291186,0.0001282481,0.00002140745,0.000002342629,0.000003813567,0.0000808624,0.000002760718,0.0001248459],"genre_scores_gemma":[0.9995876,0.00005873599,0.0002007724,0.00001372259,0.000008084132,0.000005723069,0.00007901763,0.000001998103,0.00004428887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003756484,"threshold_uncertainty_score":0.007469237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02505402724392528,"score_gpt":0.2920505830339277,"score_spread":0.2669965557900024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}