{"id":"W1619053513","doi":"10.1001/jamaneurol.2015.1700","title":"Association of Long Runs of Homozygosity With Alzheimer Disease Among African American Individuals","year":2015,"lang":"en","type":"article","venue":"JAMA Neurology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"National Center for Research Resources; National Cancer Institute; National Human Genome Research Institute; National Institute on Aging; Geriatric Research Education and Clinical Center; National Center for Advancing Translational Sciences; Medical Research Council; Department of Pathology, Johns Hopkins University; School of Medicine, Indiana University; University of California, Irvine; National Institute of Mental Health; Feinberg School of Medicine; Perelman School of Medicine, University of Pennsylvania; University of California, Davis; Canadian Institutes of Health Research; University of California, Los Angeles; National Institutes of Health; University of California, San Francisco; Alzheimer Society; University of South Florida; National Alzheimer's Coordinating Center; National Institute on Minority Health and Health Disparities; USF Health Byrd Alzheimer's Institute; Johns Hopkins University; University of Washington; University of Miami; York University; Northwestern University; Cleveland Clinic; Emory University; University of Pennsylvania; Vanderbilt University; Children's Hospital of Philadelphia; Rush University; University of California, San Diego; Office of Research and Development; U.S. Department of Veterans Affairs; Hope Center for Neurological Disorders; Wellcome Trust; University of Southern California; Massachusetts General Hospital; GlaxoSmithKline; National Institute of Neurological Disorders and Stroke; University of Pittsburgh; University of Colorado School of Medicine, Anschutz Medical Campus; Alzheimer's Association","keywords":"Runs of Homozygosity; Genetics; Single-nucleotide polymorphism; Genotype; SNP; Biology; Genome-wide association study; Inbreeding; Population; Allele; Genetic association; Disease; Allele frequency; Locus (genetics); Medicine; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002159868,0.0001402191,0.0004357141,0.0001551851,0.00002844434,0.000007142619,0.0001065584,0.00007815289,0.00003306337],"category_scores_gemma":[0.0002720245,0.0001088665,0.00008586177,0.0003374729,0.0003743201,0.00009926842,0.00006767088,0.0002369251,0.00001314936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003292171,"about_ca_system_score_gemma":0.0003368597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005429327,"about_ca_topic_score_gemma":0.00007267488,"domain_scores_codex":[0.998323,0.0002486796,0.000236554,0.0002566618,0.0006004439,0.0003346294],"domain_scores_gemma":[0.9982058,0.0001659134,0.0003663753,0.0003271098,0.0003171127,0.0006176805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001972521,0.0006962458,0.9911864,0.00001633031,0.00358813,0.0003760462,0.0001436282,0.00001098918,0.000006483752,0.00002100576,0.0008611873,0.001121028],"study_design_scores_gemma":[0.002553891,0.002266652,0.9927575,0.00001184319,0.001691094,0.00001222887,0.00004438435,0.00006004065,0.0003571248,0.00006750921,0.000103069,0.00007466571],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946085,0.0005540994,0.0000103443,0.003072299,0.00002791287,0.0004105004,0.0001007409,0.00002779056,0.001187821],"genre_scores_gemma":[0.9994203,0.00002749436,0.00006568827,0.0002751763,0.00006299953,0.00003140874,0.00007028642,0.0000212366,0.00002543733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004811781,"threshold_uncertainty_score":0.4439448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02505402724392528,"score_gpt":0.2920505830339277,"score_spread":0.2669965557900024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}