{"id":"W1621696727","doi":"10.1111/ijcp.12022","title":"Denosumab: mechanism of action and clinical outcomes","year":2012,"lang":"en","type":"review","venue":"International Journal of Clinical Practice","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":367,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; McMaster University; St. Joseph’s Healthcare Hamilton; University of Calgary","funders":"Amgen Canada; Amgen","keywords":"Medicine; Denosumab; Mechanism (biology); Mechanism of action; Action (physics); Intensive care medicine; Internal medicine; Osteoporosis; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.003205097,0.0002094962,0.001313451,0.0000950118,0.00001888319,0.00003293205,0.000467676,0.0004903633,0.00003528754],"category_scores_gemma":[0.01404522,0.0001517818,0.001276482,0.00003765529,0.0001287431,0.00004612382,0.0002219734,0.0005905275,0.00001258566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009436585,"about_ca_system_score_gemma":0.0004756972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007915601,"about_ca_topic_score_gemma":0.000002478181,"domain_scores_codex":[0.9955181,0.000892552,0.002737957,0.0002250328,0.0005055166,0.0001207959],"domain_scores_gemma":[0.9924127,0.001983314,0.004317549,0.0002295296,0.0008338697,0.0002229843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003681899,0.0007445081,0.001097067,0.0002389634,0.002498781,0.00002944598,0.000002639735,9.32292e-8,0.00000296908,0.0007230804,0.0007869157,0.9935073],"study_design_scores_gemma":[0.0006988959,0.0002471638,0.001320668,0.0003780057,0.003080095,0.00044482,0.00001707166,3.872527e-7,0.000006324036,0.0001425982,0.9935255,0.0001384608],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007664312,0.991837,0.000790823,0.0001938613,0.005707353,0.0001176401,0.00004497735,0.000002460336,0.0005394433],"genre_scores_gemma":[0.003206638,0.9903751,0.002430003,0.000354856,0.003432263,0.000001774507,0.00002946079,0.00002489771,0.0001449771],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9933689,"threshold_uncertainty_score":0.9942599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2091366442985757,"score_gpt":0.5596370278439871,"score_spread":0.3505003835454114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}