{"id":"W1623701565","doi":"10.4049/jimmunol.176.11.6777","title":"Deletion of Exon I of SMAD7 in Mice Results in Altered B Cell Responses","year":2006,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"","keywords":"Biology; Autocrine signalling; Cell biology; Signal transduction; Mutant; Phenotype; Apoptosis; Transforming growth factor; Embryonic stem cell; Immune system; Molecular biology; Immunology; Cell culture; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006620186,0.00007023708,0.0001783155,0.0001372506,0.00001078604,0.000001494885,0.0002485965,0.00009737891,0.000003770194],"category_scores_gemma":[0.0002228093,0.00005402984,0.00005472947,0.00009094039,0.0001239249,0.000003167666,0.00004829152,0.0001193809,6.711047e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001540782,"about_ca_system_score_gemma":0.0001052473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001784656,"about_ca_topic_score_gemma":0.0001158649,"domain_scores_codex":[0.998726,0.0003885042,0.0006247076,0.00006836296,0.00007464992,0.000117767],"domain_scores_gemma":[0.9990597,0.0001142007,0.0005329088,0.0001748507,0.0001089874,0.000009324634],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005801634,0.0001824526,0.001904392,0.00001210979,0.00001808227,0.000004590674,0.0001135579,0.0009051289,0.9906263,0.000006956712,0.0001624516,0.0002623816],"study_design_scores_gemma":[0.001521403,0.0005391464,0.08096603,0.00005388293,0.00001386974,0.00003842168,0.0001513817,0.000005924919,0.9161062,0.0001297067,0.000427295,0.00004668965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924905,0.007049402,0.00005833299,0.0001025505,0.00007858146,0.00005129756,0.000009434452,8.267838e-7,0.0001590775],"genre_scores_gemma":[0.9993789,0.0002517973,0.0002110114,0.00001519399,0.00004986501,6.926387e-7,0.00000767596,0.000006850387,0.00007800879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07906163,"threshold_uncertainty_score":0.2203273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00830477637004926,"score_gpt":0.2349031237038815,"score_spread":0.2265983473338322,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}