{"id":"W1624581632","doi":"10.1007/1-4020-4457-7_54","title":"Metabolic responses of eukaryotic drug efficacy and toxicity","year":2006,"lang":"en","type":"book-chapter","venue":"","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Phenomenome Discoveries (Canada)","funders":"","keywords":"Drug; Pharmacology; Toxicity; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003041249,0.0003326576,0.0003354892,0.0002772807,0.0001520543,0.0007201466,0.0003107145,0.0006125245,0.001468099],"category_scores_gemma":[0.0006174851,0.0002410721,0.0003550382,0.0003922988,0.0004311134,0.0006497604,0.0003137483,0.000594861,0.0004947166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007452935,"about_ca_system_score_gemma":0.0001539923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004215729,"about_ca_topic_score_gemma":0.0003804035,"domain_scores_codex":[0.9996982,0.00006463355,0.00002305653,0.00005446799,0.0001197218,0.00003995839],"domain_scores_gemma":[0.9997985,0.0000938109,0.00003013444,0.00001475372,0.00004958067,0.00001326709],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0004447877,0.00003221466,0.0006583317,0.000114215,0.00001236279,0.0001185949,0.00005723043,0.001655211,0.9706839,0.005261167,0.0004154044,0.02054641],"study_design_scores_gemma":[0.0000148474,0.0002932988,0.009369086,0.00002080882,0.00001629757,0.000418186,0.0001102953,0.006187345,0.9698304,0.006184811,0.007523151,0.00003155955],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8568585,0.04350324,0.04626348,0.002285896,0.0002756761,0.00009583682,0.001756146,0.0006765188,0.04828472],"genre_scores_gemma":[0.9823584,0.00635025,0.00298702,0.0003133606,0.00005878383,0.00003582325,0.0003188637,0.00005893056,0.007518524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001468099,"threshold_uncertainty_score":0.005407512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007271413218052076,"score_gpt":0.2100458233945924,"score_spread":0.2027744101765403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}