{"id":"W1626267121","doi":"10.1038/35024009","title":"Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing","year":2000,"lang":"en","type":"article","venue":"Nature","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":904,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network; Toronto Western Hospital","funders":"National Center for Theoretical Sciences","keywords":"Nicastrin; Presenilin; Cell biology; Caenorhabditis elegans; Biology; Amyloid precursor protein; Notch signaling pathway; Amyloid precursor protein secretase; Biochemistry; Signal transduction; Alzheimer's disease; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004636674050715461,"score_gpt":0.2227353939918565,"score_spread":0.2180987199411411,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}