{"id":"W1626583747","doi":"10.1002/mds.26354","title":"Disease‐modifying strategies for Parkinson's disease","year":2015,"lang":"en","type":"review","venue":"Movement Disorders","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":258,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; Toronto Western Hospital; University of Toronto; University Health Network","funders":"Edmond J. Safra Philanthropic Foundation; Parkinson Society Canada; Michael J. Fox Foundation for Parkinson's Research; W. Garfield Weston Foundation; Canadian Institutes of Health Research; National Parkinson Foundation; Parkinson's UK","keywords":"Medicine; Clinical trial; Disease; Parkinson's disease; Bioinformatics; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001482017,0.0004641268,0.0005213879,0.0000861575,0.0001157974,0.0001200042,0.0003116498,0.0001447747,0.00003484817],"category_scores_gemma":[0.00006631021,0.0004167945,0.0006853782,0.00009298076,0.00007646569,0.000009010417,0.000120643,0.00006508936,0.00001657967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005666798,"about_ca_system_score_gemma":0.001117507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005784174,"about_ca_topic_score_gemma":0.00001471237,"domain_scores_codex":[0.9982569,0.00008020025,0.0003707024,0.0006630254,0.0002574227,0.0003717563],"domain_scores_gemma":[0.9985012,0.00001271088,0.0002131254,0.0006144145,0.00007239225,0.0005861013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000324104,0.0004353524,0.0003362235,0.01539667,0.0004047132,0.000005688108,0.00001602313,0.0003065258,0.000004238736,0.003107143,0.1099498,0.8697135],"study_design_scores_gemma":[0.0005532968,0.00005228813,0.00007469826,0.0004693228,0.0005062979,2.225404e-8,0.00007037655,0.0000630932,1.823316e-7,0.009163677,0.9885339,0.000512888],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003595854,0.9941211,0.002384793,0.0001580676,0.0002444135,0.001664003,0.0006393986,0.00003574141,0.0007164605],"genre_scores_gemma":[0.000269684,0.9909979,0.00009640906,0.0007948036,0.0002809881,0.00114797,0.004550131,0.0000918927,0.001770247],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.878584,"threshold_uncertainty_score":0.9998284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04038320774482855,"score_gpt":0.3300926324669579,"score_spread":0.2897094247221293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}