{"id":"W1627267625","doi":"10.1073/pnas.202612199","title":"Progesterone receptor knockout mice have an improved glucose homeostasis secondary to β-cell proliferation","year":2002,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":165,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; Canadian Institutes of Health Research; Centre National de la Recherche Scientifique; European Commission; Association pour la Recherche sur le Cancer","keywords":"Internal medicine; Endocrinology; Glucose homeostasis; Insulin; Progesterone receptor; Pancreatic islets; Receptor; Diabetes mellitus; Mifepristone; Homeostasis; Knockout mouse; Biology; Islet; Insulin resistance; Medicine; Pregnancy; Estrogen receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002096085,0.0007568327,0.000499585,0.0007780496,0.0002706048,0.0005777177,0.0002751825,0.0005080691,0.004765219],"category_scores_gemma":[0.0002995895,0.0005035364,0.0003535513,0.000303163,0.0004163325,0.0003471666,0.0003297011,0.001009659,0.001515718],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002153523,"about_ca_system_score_gemma":0.0001541142,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003499262,"about_ca_topic_score_gemma":0.0005236414,"domain_scores_codex":[0.9996623,0.00003625522,0.00004413667,0.0001043972,0.00009559706,0.00005746021],"domain_scores_gemma":[0.9994845,0.00004331981,0.00023929,0.00005554481,0.00001955046,0.0001577306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002829526,0.00001950053,0.0004534774,0.0000419057,0.000009433329,0.0002123359,0.00002567842,0.00001780019,0.9966763,0.0001585185,0.00009044703,0.002011703],"study_design_scores_gemma":[0.0002468989,0.0009357714,0.03836277,0.00004063323,0.00009533137,0.00836568,0.0001265507,0.0003874683,0.93997,0.0003587945,0.01108603,0.00002407758],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844982,0.002799865,0.005824706,0.0005710349,0.0001266707,0.00003272017,0.002287832,0.0005036586,0.003355347],"genre_scores_gemma":[0.9685597,0.00444197,0.006133905,0.0002063851,0.00008757418,0.000108794,0.00214208,0.0003598333,0.01795976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004765219,"threshold_uncertainty_score":0.0159412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03935348858138805,"score_gpt":0.286266000645337,"score_spread":0.246912512063949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}