{"id":"W1627803359","doi":"10.1007/s11523-015-0386-5","title":"Simultaneous Targeting of Bladder Tumor Growth, Survival, and Epithelial-to-Mesenchymal Transition with a Novel Therapeutic Combination of Acetazolamide (AZ) and Sulforaphane (SFN)","year":2015,"lang":"en","type":"article","venue":"Targeted Oncology","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Medicine; Cancer research; Sulforaphane; Protein kinase B; PI3K/AKT/mTOR pathway; Clonogenic assay; Apoptosis; Bladder cancer; Epithelial–mesenchymal transition; Survivin; Pharmacology; Cancer; Internal medicine; Chemistry; Metastasis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001026184,0.0002747791,0.0002788701,0.000171151,0.0001358674,0.0001786473,0.0001943643,0.0001470434,0.0007723453],"category_scores_gemma":[0.0000615872,0.00008158372,0.0001792657,0.0001610351,0.000196799,0.0001672716,0.0001480169,0.0003725883,0.00008161142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002384564,"about_ca_system_score_gemma":0.0004836489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009741575,"about_ca_topic_score_gemma":0.003363299,"domain_scores_codex":[0.9999326,0.000009051362,0.000004180881,0.00001295552,0.00001680897,0.00002432813],"domain_scores_gemma":[0.9999728,0.000004186072,0.00000803957,0.000003492368,0.000002496552,0.000009044271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008457323,0.0001557515,0.0004120797,0.00006316344,0.00001710749,0.00005494459,0.00001655266,0.000390165,0.9846821,0.0002880788,0.000155837,0.0129185],"study_design_scores_gemma":[0.0002190065,0.003365615,0.003741577,0.000007975355,0.00008605913,0.0003536369,0.00003362673,0.002466138,0.9852372,0.0001013202,0.004377931,0.000009918072],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926058,0.001967074,0.003046877,0.0001733183,0.00004211093,0.00005531056,0.0001517784,0.00007562429,0.001882081],"genre_scores_gemma":[0.9970405,0.000710911,0.001401566,0.00002310171,0.000009445707,0.00002433037,0.00006794582,0.000003794911,0.0007184518],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009741575,"threshold_uncertainty_score":0.002583802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01358908671145698,"score_gpt":0.2522022828085155,"score_spread":0.2386131960970586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}