{"id":"W1627803359","doi":"10.1007/s11523-015-0386-5","title":"Simultaneous Targeting of Bladder Tumor Growth, Survival, and Epithelial-to-Mesenchymal Transition with a Novel Therapeutic Combination of Acetazolamide (AZ) and Sulforaphane (SFN)","year":2015,"lang":"en","type":"article","venue":"Targeted Oncology","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Medicine; Cancer research; Sulforaphane; Protein kinase B; PI3K/AKT/mTOR pathway; Clonogenic assay; Apoptosis; Bladder cancer; Epithelial–mesenchymal transition; Survivin; Pharmacology; Cancer; Internal medicine; Chemistry; Metastasis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002787308,0.0001755629,0.0003568955,0.00007556977,0.00003497579,0.000005856201,0.00009770469,0.0001455981,0.000005271632],"category_scores_gemma":[0.0001805709,0.0001577991,0.00003485583,0.0001082664,0.0002865931,0.000007704944,0.00005355718,0.00009035424,5.945279e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001851189,"about_ca_system_score_gemma":0.0001207723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006735767,"about_ca_topic_score_gemma":0.00005272898,"domain_scores_codex":[0.9989416,0.00009736388,0.0002981008,0.0003215154,0.0001194762,0.0002219148],"domain_scores_gemma":[0.9990661,0.00008548232,0.0001960929,0.0001350151,0.0003922556,0.0001250142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009793129,0.0002034155,0.001177519,0.00005299285,0.0001060658,0.000004138152,0.0006813885,0.0002408323,0.9958898,0.0001625107,0.00002897553,0.0004730853],"study_design_scores_gemma":[0.003652659,0.003448374,0.002570451,0.00001908751,0.00008380691,0.00003973966,0.001304042,0.0006250959,0.9868835,0.0005339225,0.0005819668,0.0002573287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919531,0.000636985,0.006452534,0.0002498186,0.00007220932,0.0003340946,0.0001205742,0.00000814193,0.0001725953],"genre_scores_gemma":[0.9964445,0.00007894139,0.003085288,0.0001358876,0.00006005305,0.00001392951,0.0001388391,0.0000220589,0.00002050445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009006238,"threshold_uncertainty_score":0.6434863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01358908671145698,"score_gpt":0.2522022828085155,"score_spread":0.2386131960970586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}