{"id":"W1629430930","doi":"10.4049/jimmunol.1302832","title":"Lyn Deficiency Leads to Increased Microbiota-Dependent Intestinal Inflammation and Susceptibility to Enteric Pathogens","year":2014,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"LYN; Citrobacter rodentium; Immune system; Immunology; Dysbiosis; Biology; Colitis; Salmonella enterica; Microbiology; Inflammation; Inflammatory bowel disease; Intestinal permeability; Gut flora; Medicine; Disease; Salmonella; Tyrosine kinase; Internal medicine; Bacteria; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002280405,0.0007398443,0.0005851374,0.000753514,0.0003004422,0.0005464747,0.000324443,0.0007084787,0.00203413],"category_scores_gemma":[0.0003388214,0.0004593252,0.0003503045,0.0002910435,0.0006600586,0.00026875,0.0005612799,0.0007123672,0.0004240879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003903738,"about_ca_system_score_gemma":0.0003309538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007331609,"about_ca_topic_score_gemma":0.001078182,"domain_scores_codex":[0.999582,0.00009300738,0.00005977878,0.0001034718,0.00007160393,0.00009005975],"domain_scores_gemma":[0.9993869,0.00008405557,0.0002121549,0.00004278461,0.00002490633,0.0002491751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001010836,0.00006512397,0.0005298962,0.00003685081,0.00001276342,0.0003318161,0.0000225407,0.0001295258,0.9968612,0.0001111007,0.00005062302,0.0008377761],"study_design_scores_gemma":[0.0004498637,0.002833087,0.0457708,0.0001153017,0.000205362,0.007896905,0.0003820961,0.004914081,0.9322838,0.0006539806,0.004421095,0.00007357744],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972241,0.0007397982,0.0009092162,0.00009443354,0.00002863417,0.00001781254,0.0003432866,0.00007329558,0.0005694767],"genre_scores_gemma":[0.9964126,0.0005694628,0.0009284813,0.00005814134,0.00001317565,0.00002816574,0.0003144461,0.00004045745,0.001635148],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00203413,"threshold_uncertainty_score":0.006804824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00873993069633532,"score_gpt":0.223857896910519,"score_spread":0.2151179662141836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}