{"id":"W1631759172","doi":"10.4049/jimmunol.1302896","title":"NADPH Oxidase Modifies Patterns of MHC Class II–Restricted Epitopic Repertoires through Redox Control of Antigen Processing","year":2014,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Experimental autoimmune encephalomyelitis; MHC class II; Phagosome; Myelin oligodendrocyte glycoprotein; Cell biology; NADPH oxidase; Proteolysis; T cell; Biology; Antigen-presenting cell; Chemistry; MHC restriction; Dendritic cell; Cathepsin; Antigen presentation; Antigen; Biochemistry; Immunology; Immune system; Phagocytosis; Reactive oxygen species; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001071306,0.000232386,0.0001051222,0.0001267935,0.00007220812,0.0002430284,0.0001467426,0.0001408733,0.0006076974],"category_scores_gemma":[0.00009798749,0.00009530861,0.0001133221,0.00007386688,0.0001347306,0.0001541283,0.000119691,0.0002535789,0.000127592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001245281,"about_ca_system_score_gemma":0.00009172541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002191105,"about_ca_topic_score_gemma":0.0003551179,"domain_scores_codex":[0.9999136,0.0000128246,0.00000471527,0.00002483241,0.00001709047,0.00002697088],"domain_scores_gemma":[0.9999378,0.000005386277,0.00002217679,0.000008019134,0.000009563822,0.00001707171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004087101,0.000004499477,0.0003131048,0.000004386629,0.000001618238,0.00001645906,0.000003957222,0.00001261581,0.9990906,0.0000406045,0.000006255424,0.0004650686],"study_design_scores_gemma":[0.00001054233,0.0001976124,0.01871688,0.000003507639,0.0000176644,0.000304186,0.00003646528,0.0007449054,0.978555,0.0001395207,0.001268935,0.00000486277],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969118,0.0004586371,0.001947642,0.00002925977,0.00001173587,0.000006312584,0.00007437896,0.00002632095,0.00053394],"genre_scores_gemma":[0.9978135,0.0003084628,0.001027885,0.00001959941,0.00000558088,0.000005962134,0.00009018026,0.000007716657,0.0007211118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006076974,"threshold_uncertainty_score":0.002032936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008651025899292475,"score_gpt":0.2261421901345251,"score_spread":0.2174911642352326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}