{"id":"W1631759172","doi":"10.4049/jimmunol.1302896","title":"NADPH Oxidase Modifies Patterns of MHC Class II–Restricted Epitopic Repertoires through Redox Control of Antigen Processing","year":2014,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Experimental autoimmune encephalomyelitis; MHC class II; Phagosome; Myelin oligodendrocyte glycoprotein; Cell biology; NADPH oxidase; Proteolysis; T cell; Biology; Antigen-presenting cell; Chemistry; MHC restriction; Dendritic cell; Cathepsin; Antigen presentation; Antigen; Biochemistry; Immunology; Immune system; Phagocytosis; Reactive oxygen species; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007675239,0.0001708931,0.0006300066,0.0001824618,0.0002167584,0.000005584073,0.0005103764,0.0002745635,0.00007651812],"category_scores_gemma":[0.0005203172,0.0001101901,0.0001575368,0.0001358532,0.0004356498,0.0002149983,0.00008833065,0.0004434544,0.000008012359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002809221,"about_ca_system_score_gemma":0.0001399958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002040194,"about_ca_topic_score_gemma":0.000006256168,"domain_scores_codex":[0.9973652,0.001118205,0.001064314,0.0001010941,0.00007174833,0.0002794515],"domain_scores_gemma":[0.9971837,0.0004559936,0.001552194,0.0003661447,0.000432971,0.000008972068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002009873,0.000112708,0.001339953,0.00003666485,0.0004226257,0.000002263954,0.002045152,0.00005310944,0.978323,0.0007527579,0.00008693297,0.01481497],"study_design_scores_gemma":[0.003208572,0.00159186,0.03254914,0.0002192518,0.0001738304,0.0004952294,0.000970205,0.00004677743,0.9500815,0.0007958921,0.009730968,0.0001367912],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9801568,0.01423306,0.003818808,0.0009805993,0.0004687829,0.0001361127,0.000005858484,0.00001273887,0.0001872544],"genre_scores_gemma":[0.9981899,0.001370439,0.00004772313,0.00007481014,0.00004976744,0.000002275282,0.000006743027,0.00001339514,0.0002450006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03120919,"threshold_uncertainty_score":0.4493422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008651025899292475,"score_gpt":0.2261421901345251,"score_spread":0.2174911642352326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}