{"id":"W1632777851","doi":"10.4049/jimmunol.166.2.855","title":"VH Gene Replacement in Thymocytes","year":2001,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Biology; Gene; Somatic hypermutation; Locus (genetics); Molecular biology; Genetics; Gene rearrangement; CD8; Immunoglobulin heavy chain; B cell; Antibody; Antigen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001603058,0.0001571429,0.0001584726,0.000174321,0.000134837,0.0003449546,0.0002612693,0.0002776702,0.001092549],"category_scores_gemma":[0.0001659813,0.0001201307,0.0001860467,0.00009596367,0.0001879273,0.0001223168,0.0002322422,0.0004844605,0.0003127097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002524971,"about_ca_system_score_gemma":0.0001299522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002194144,"about_ca_topic_score_gemma":0.0003300297,"domain_scores_codex":[0.9997813,0.00003534559,0.00002261181,0.00005627884,0.00005047151,0.00005398838],"domain_scores_gemma":[0.9998627,0.00003363151,0.00003110561,0.00002823692,0.00001423155,0.00003011273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001950547,0.000006971046,0.0001816957,0.00001336401,0.000001569535,0.00005305845,0.00001136163,0.00001785432,0.9985275,0.0001650678,0.00001165367,0.0009903604],"study_design_scores_gemma":[0.00001874005,0.0002567407,0.002442313,0.000004951106,0.00001279712,0.0006240522,0.00002633044,0.0003749595,0.9923891,0.0001002376,0.003746085,0.000003685956],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993803,0.0004785855,0.00389469,0.00004974237,0.00003549689,0.0000313583,0.0001833865,0.00008354257,0.001440168],"genre_scores_gemma":[0.9940767,0.0002599023,0.002291414,0.00006031806,0.00001108126,0.00001782755,0.0002866067,0.00004033021,0.002955726],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001092549,"threshold_uncertainty_score":0.003654957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01326553069668568,"score_gpt":0.231155892023766,"score_spread":0.2178903613270803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}