{"id":"W1636205509","doi":"10.1056/nejmoa1502214","title":"<i>FTO</i> Obesity Variant Circuitry and Adipocyte Browning in Humans","year":2015,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1396,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Institute of General Medical Sciences; Helmholtz Zentrum München; Canadian Institutes of Health Research; National Institutes of Health; Hospital for Sick Children; National Human Genome Research Institute; Technische Universität München; Australian Government; Heart and Stroke Foundation of Canada","keywords":"Biology; Derepression; Adipocyte; Thermogenesis; Enhancer; Adipogenesis; Adipose tissue; Gene knockdown; Genetics; Transcription factor; Endocrinology; Internal medicine; Gene; Gene expression; Medicine; Psychological repression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001717221,0.0004459031,0.0001850321,0.0006385482,0.0002928888,0.0003112312,0.0002424672,0.0003951715,0.005531788],"category_scores_gemma":[0.0002906545,0.00009612725,0.0003984873,0.0004503531,0.0003924361,0.0001109418,0.0002315826,0.0003568828,0.0003521892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001962492,"about_ca_system_score_gemma":0.0001289652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001636437,"about_ca_topic_score_gemma":0.001826636,"domain_scores_codex":[0.9998826,0.00001501645,0.00001218249,0.00006198585,0.00001443696,0.00001380644],"domain_scores_gemma":[0.9998488,0.00002610242,0.0000859779,0.00001116343,0.000006684688,0.0000213158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006507996,0.0002171727,0.4644195,0.0003965612,0.001065986,0.01013084,0.0004395841,0.001759101,0.4617038,0.003159593,0.00549657,0.04470338],"study_design_scores_gemma":[0.000167447,0.0004180875,0.9460804,0.0001194571,0.0006279619,0.01957792,0.0001430214,0.002071041,0.02130891,0.002319886,0.007111129,0.00005483111],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920095,0.0007128068,0.002691859,0.0003733762,0.00003642913,0.00002148126,0.002173989,0.0001394179,0.001841175],"genre_scores_gemma":[0.9962776,0.0001781735,0.001541537,0.0001834598,0.00003633513,0.00002340274,0.001097018,0.00004264105,0.0006196608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005531788,"threshold_uncertainty_score":0.01850569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02599456998332688,"score_gpt":0.2727131814022883,"score_spread":0.2467186114189614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}