{"id":"W1636230558","doi":"10.1016/j.neuropharm.2015.08.020","title":"Forkhead box O transcription factors as possible mediators in the development of major depression","year":2015,"lang":"en","type":"review","venue":"Neuropharmacology","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; McGill University; Douglas Mental Health University Institute","funders":"China Postdoctoral Science Foundation; Natural Science Foundation of Guangdong Province; National Natural Science Foundation of China","keywords":"Synaptogenesis; Neurogenesis; Neuroscience; Transcription factor; Depression (economics); Monoaminergic; Biology; Psychology; Receptor; Serotonin; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004173955,0.0006010326,0.0009798066,0.0008565171,0.0001915593,0.0007296184,0.0007406535,0.0007700176,0.001778596],"category_scores_gemma":[0.000428588,0.0001659024,0.0003249132,0.0009176299,0.0004650466,0.0006714009,0.0006207399,0.001320097,0.0005683351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005208262,"about_ca_system_score_gemma":0.0009205408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001147953,"about_ca_topic_score_gemma":0.002605493,"domain_scores_codex":[0.9999115,0.00001203215,0.00001242692,0.00002042703,0.00002926483,0.00001426396],"domain_scores_gemma":[0.9998785,0.00004995801,0.00002332641,0.000003914943,0.00002702493,0.00001722184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002034476,0.0000580905,0.0004397568,0.01139178,0.0001531548,0.0003232066,0.00005446762,0.0003446492,0.003824767,0.005461506,0.02109723,0.956648],"study_design_scores_gemma":[0.00006307065,0.0001272343,0.002534618,0.003497868,0.0003504402,0.001485862,0.0001116372,0.0002090369,0.001436593,0.005781454,0.984367,0.00003526983],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001583766,0.9989581,0.0001300923,0.000255186,0.0001311641,0.000001863661,0.00001514198,0.000004574223,0.0003454398],"genre_scores_gemma":[0.001198168,0.99804,0.0001461407,0.0001448847,0.0001444537,0.000002915383,0.0000233496,8.886328e-7,0.0002991823],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001778596,"threshold_uncertainty_score":0.005950034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0552139696936975,"score_gpt":0.3598579336297794,"score_spread":0.3046439639360819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}