{"id":"W1636692034","doi":"10.1002/rmv.1853","title":"Protein/peptide‐based entry/fusion inhibitors as anti‐HIV therapies: challenges and future direction","year":2015,"lang":"en","type":"review","venue":"Reviews in Medical Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research","keywords":"Enfuvirtide; Human immunodeficiency virus (HIV); Peptide; Medicine; Drug; Computational biology; Clinical trial; Pharmacology; Biology; Virology; Gp41; Immunology; Biochemistry; Internal medicine; Epitope; Antigen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.002738942,0.0006529363,0.003297593,0.0003652975,0.0001118338,0.00001025257,0.0004006878,0.00218328,0.00161207],"category_scores_gemma":[0.0007005304,0.0004006366,0.0003716926,0.0002429881,0.0005596052,0.00005001151,0.0002065736,0.001788891,0.003498762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001649327,"about_ca_system_score_gemma":0.0005869861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002619923,"about_ca_topic_score_gemma":0.00005658943,"domain_scores_codex":[0.9924496,0.004630473,0.001112597,0.0008834751,0.0001978425,0.0007259922],"domain_scores_gemma":[0.9984313,0.0003626351,0.0004028966,0.0005452028,0.00004696894,0.0002110431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003977493,0.0002901415,0.000007747423,0.005831368,0.000160773,0.0001319136,0.0001247001,6.587168e-9,0.000009203952,0.0001199168,0.003847179,0.9894373],"study_design_scores_gemma":[0.001292367,0.0005404322,0.00002010069,0.009775623,0.0001738756,0.0002902261,0.00003334757,2.670997e-7,0.00000311922,0.00004918566,0.987525,0.0002963946],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001326473,0.9926063,0.00000185413,0.002246,0.0006630296,0.002859772,0.00003420782,0.00004904428,0.001407106],"genre_scores_gemma":[0.00001908944,0.9967995,0.00003083436,0.0001801073,0.000456152,0.001223461,0.0006838515,0.00004548961,0.000561535],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9891409,"threshold_uncertainty_score":0.9998446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04661965197020546,"score_gpt":0.3499346437298625,"score_spread":0.303314991759657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}