{"id":"W1637147963","doi":"10.1016/j.molmed.2015.06.006","title":"Phosphoinositide signaling in cancer: INPP4B Akt(s) out","year":2015,"lang":"en","type":"article","venue":"Trends in Molecular Medicine","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Suppressor; Protein kinase B; PI3K/AKT/mTOR pathway; Cancer research; Cancer; Breast cancer; Signal transduction; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005242847,0.0006271558,0.0004000169,0.0006176467,0.0006109486,0.00164415,0.0004436469,0.0006300314,0.008624705],"category_scores_gemma":[0.0002039492,0.0002929388,0.0003593632,0.0006293146,0.0005855235,0.001091867,0.0006573604,0.001781128,0.002426928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001182887,"about_ca_system_score_gemma":0.001173755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001194855,"about_ca_topic_score_gemma":0.00182388,"domain_scores_codex":[0.9998583,0.0000145648,0.00001040138,0.00002835623,0.00003956542,0.0000488627],"domain_scores_gemma":[0.9998949,0.000004808611,0.00002176428,0.000008687761,0.00002272594,0.00004704422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.005321124,0.0008329272,0.006108855,0.002071844,0.0002310378,0.001803493,0.0002971622,0.001411883,0.5916225,0.0613694,0.05363382,0.275296],"study_design_scores_gemma":[0.0006294429,0.001339785,0.03027053,0.0005216941,0.0004701289,0.004481283,0.0006780504,0.004647068,0.3928933,0.01856535,0.5454224,0.00008103922],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.4344273,0.3554131,0.01342672,0.05699712,0.007948922,0.0001843802,0.002796281,0.001396174,0.12741],"genre_scores_gemma":[0.8153258,0.122387,0.004757762,0.003544909,0.00118264,0.00007765007,0.0009429317,0.0001416734,0.05163972],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.008624705,"threshold_uncertainty_score":0.02885252,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03989774162099946,"score_gpt":0.3466716261947489,"score_spread":0.3067738845737494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}