{"id":"W1638855221","doi":"10.1158/1535-7163.mct-06-0562","title":"Mechanism and functional role of XIAP and Mcl-1 down-regulation in flavopiridol/vorinostat antileukemic interactions","year":2007,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute; Leukemia and Lymphoma Society; V Foundation for Cancer Research; U.S. Department of Defense","keywords":"XIAP; Vorinostat; Clonogenic assay; Cancer research; Chemistry; Apoptosis; Biology; Cell biology; Histone deacetylase; Histone; Programmed cell death; Caspase; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001198192,0.0002968566,0.0001921679,0.000205445,0.000122646,0.0002523147,0.0001954938,0.0002147575,0.000969122],"category_scores_gemma":[0.00008010228,0.000119604,0.0002157654,0.0001062337,0.0001892136,0.0002594238,0.0001412088,0.0002985801,0.000207061],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003182495,"about_ca_system_score_gemma":0.00009141838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001972461,"about_ca_topic_score_gemma":0.0002285594,"domain_scores_codex":[0.9999169,0.00001646077,0.000006985241,0.00001876634,0.00001944322,0.00002141185],"domain_scores_gemma":[0.9999558,0.000008484922,0.00001593789,0.00000561358,0.000005495152,0.000008629412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001348046,0.00001234847,0.00024346,0.0000288664,0.000005039877,0.00009285533,0.00001117941,0.00006740567,0.9977908,0.0001535417,0.00001850124,0.001441283],"study_design_scores_gemma":[0.00003278685,0.0003361001,0.009687223,0.00000604088,0.00002173107,0.0004473834,0.00003304974,0.001057028,0.986237,0.0001457455,0.001991187,0.000004623252],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895878,0.006238225,0.002699279,0.0001095335,0.00001705232,0.00002626706,0.0001856234,0.0000693634,0.001066756],"genre_scores_gemma":[0.9972959,0.001066607,0.0006332144,0.00003161512,0.000007420045,0.0000236853,0.0001927233,0.000003123331,0.0007457534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000969122,"threshold_uncertainty_score":0.003242016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01205887505269926,"score_gpt":0.263187212290849,"score_spread":0.2511283372381498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}