{"id":"W1643393773","doi":"10.1111/febs.13405","title":"Lipid binding protein response to a bile acid library: a combined NMR and statistical approach","year":2015,"lang":"en","type":"article","venue":"FEBS Journal","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Amino acid; Ligand (biochemistry); Taurine; Stereochemistry; Binding site; Biochemistry; Nuclear magnetic resonance spectroscopy; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001321684,0.0003892003,0.0008930946,0.00149895,0.0003165658,0.0006535268,0.0004194606,0.0004824343,0.0005642841],"category_scores_gemma":[0.002327811,0.0001725637,0.001027282,0.001165525,0.0004373686,0.0004214682,0.0005222831,0.0004623596,0.0001841098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004243101,"about_ca_system_score_gemma":0.0006926855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002084058,"about_ca_topic_score_gemma":0.001619878,"domain_scores_codex":[0.9994338,0.0002020441,0.00002621879,0.0001590579,0.0001130295,0.00006580959],"domain_scores_gemma":[0.9987035,0.0007295261,0.0001428173,0.0001669579,0.0001741035,0.00008309465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001242958,0.0008558027,0.02359363,0.0004427419,0.0009882917,0.0002652648,0.0002552292,0.2949057,0.5495285,0.00703053,0.001315758,0.1195756],"study_design_scores_gemma":[0.00001702477,0.0002875992,0.01340564,0.000004053088,0.0001333652,0.00006254113,0.00005062495,0.9622571,0.02039303,0.002637183,0.0007061731,0.00004569258],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7857639,0.0003303791,0.2107422,0.0001913078,0.00002502014,0.00008399952,0.0007008557,0.001021376,0.001141098],"genre_scores_gemma":[0.9489111,0.0002450128,0.04844701,0.00009911335,0.00004346391,0.0001930734,0.001264825,0.0001138211,0.0006825955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002084058,"threshold_uncertainty_score":0.006989837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02448367320562999,"score_gpt":0.2580527925476729,"score_spread":0.2335691193420429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}