{"id":"W1646874273","doi":"10.4049/jimmunol.174.1.507","title":"SHIP Down-Regulates FcεR1-Induced Degranulation at Supraoptimal IgE or Antigen Levels","year":2005,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"Terry Fox Research Institute; BC Cancer Agency","funders":"","keywords":"Degranulation; Immunoglobulin E; Chemistry; Cell biology; Calcium in biology; Intracellular; Molecular biology; Immunology; Receptor; Biology; Antibody; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000820565,0.0002199838,0.000456075,0.0001827043,0.0003707854,0.00001280418,0.0005187003,0.0003250389,0.005368622],"category_scores_gemma":[0.00009534662,0.0001277596,0.0001508669,0.0001408397,0.0003230482,0.0001624608,0.000133966,0.0005419723,0.0006509138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001163499,"about_ca_system_score_gemma":0.0001040198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005522822,"about_ca_topic_score_gemma":0.0001710119,"domain_scores_codex":[0.9982066,0.0004508519,0.0007012871,0.0001382403,0.00006146786,0.0004415237],"domain_scores_gemma":[0.9985151,0.0003502098,0.0005937047,0.0003321041,0.0001840167,0.00002481517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002145864,0.0001108579,0.0004478333,0.000005302018,0.0003761083,0.00001095281,0.001086504,0.00007060791,0.9803829,0.0003144919,0.001783963,0.01326467],"study_design_scores_gemma":[0.004456453,0.001621842,0.09452557,0.0000545712,0.0002144892,0.005194032,0.0004461064,0.00002541091,0.7402707,0.0001589072,0.1526853,0.0003466439],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878576,0.007952283,0.0001137464,0.002144747,0.0008013733,0.0001348398,0.0000113377,0.00002296243,0.0009611187],"genre_scores_gemma":[0.991392,0.0005212653,0.000241225,0.000184501,0.0001635209,0.000001479982,0.00001472271,0.00002121511,0.007460095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2401122,"threshold_uncertainty_score":0.9955406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02929761899045176,"score_gpt":0.2519511200881587,"score_spread":0.222653501097707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}