{"id":"W1647140950","doi":"","title":"Metformin mediated AMPK activation inhibits translation initiation in breast cancer cells","year":2007,"lang":"en","type":"article","venue":"Cancer Research","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Metformin; AMPK; PI3K/AKT/mTOR pathway; P70-S6 Kinase 1; Protein kinase A; AMP-activated protein kinase; mTORC1; Endocrinology; Cell growth; Cancer research; Internal medicine; Chemistry; Kinase; Signal transduction; Biology; Cell biology; Medicine; Biochemistry; Insulin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000216114,0.0003670613,0.0005417858,0.0004026675,0.0003276327,0.0004201801,0.0002179503,0.000304905,0.002159319],"category_scores_gemma":[0.0001492639,0.0002396179,0.0004065183,0.0005614437,0.0001159821,0.0001463704,0.0001754206,0.000669817,0.001387007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004119612,"about_ca_system_score_gemma":0.0003572033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001338686,"about_ca_topic_score_gemma":0.002484474,"domain_scores_codex":[0.9997217,0.00004396009,0.00004068304,0.00003791071,0.00008889147,0.00006685518],"domain_scores_gemma":[0.9999319,0.00001651373,0.00001494017,0.00001017147,0.00001632529,0.0000101634],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005699836,0.0001962356,0.0002044986,0.0002335174,0.00002391163,0.00009018158,0.0000278532,0.000116038,0.9911692,0.0001682794,0.001142006,0.006058297],"study_design_scores_gemma":[0.0001133303,0.0008377367,0.005352904,0.00002664183,0.00003928417,0.0003593802,0.00004001507,0.001751862,0.9694503,0.00007012297,0.02194826,0.00001014495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9420224,0.03634826,0.003569388,0.00112691,0.0008493495,0.0002159228,0.004475859,0.0003162056,0.01107572],"genre_scores_gemma":[0.93194,0.02980673,0.008945939,0.0007977673,0.0001672696,0.0004052902,0.01341091,0.00006447317,0.01446163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002159319,"threshold_uncertainty_score":0.007223666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05759414244336104,"score_gpt":0.3833207891994448,"score_spread":0.3257266467560838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}