{"id":"W1648920497","doi":"10.1002/9783527684403.ch2","title":"Use of Chemical Genomics to Investigate the Mechanism of Action for Inhibitory Bioactive Natural Compounds","year":2014,"lang":"en","type":"other","venue":"","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Carleton University","funders":"","keywords":"Inhibitory postsynaptic potential; Mechanism (biology); Action (physics); Natural (archaeology); Mechanism of action; Genomics; Computational biology; Chemistry; Biology; Biochemistry; Neuroscience; Genome; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002184957,0.0003341919,0.0003424101,0.0005294848,0.000167885,0.000586644,0.0002509402,0.0002362392,0.00157078],"category_scores_gemma":[0.0001472693,0.0001363978,0.0003242884,0.0004260854,0.0002844309,0.000312626,0.0002634434,0.0004893433,0.000477541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005154887,"about_ca_system_score_gemma":0.0003332337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008822007,"about_ca_topic_score_gemma":0.001261942,"domain_scores_codex":[0.9999102,0.0000116266,0.000005858907,0.00002811396,0.00003389687,0.00001026603],"domain_scores_gemma":[0.9999191,0.00002940911,0.00002331619,0.00001105528,0.000009919666,0.000007245308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005239078,0.00003243149,0.0005458287,0.00008658529,0.000008006177,0.00004114192,0.00001575197,0.0006400088,0.9827002,0.001642717,0.00008518116,0.01414985],"study_design_scores_gemma":[0.00001368986,0.0002325669,0.006054703,0.00001230275,0.00005226339,0.0002644242,0.00005484489,0.003169714,0.9731802,0.00152895,0.01542333,0.00001304304],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.7834446,0.01120741,0.1526136,0.001220116,0.0001396682,0.0004359407,0.007878647,0.00189213,0.041168],"genre_scores_gemma":[0.8513969,0.01126863,0.1224624,0.0006164378,0.00004260576,0.0001925252,0.004086258,0.0002178044,0.009716489],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.00157078,"threshold_uncertainty_score":0.005254805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04045151296258882,"score_gpt":0.2620432629848031,"score_spread":0.2215917500222143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}