{"id":"W164894659","doi":"10.1093/ofid/ofu051.99","title":"1211A Phase 3, Randomized, Double-Blind, Non-Inferiority Trial to Evaluate Efficacy and Safety of Isavuconazole versus Voriconazole in Patients with Invasive Mold Disease (SECURE): Outcomes in Invasive Aspergillosis Patients","year":2014,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; CancerCare Manitoba","funders":"","keywords":"Voriconazole; Medicine; Aspergillosis; Randomized controlled trial; Clinical trial; Internal medicine; Intensive care medicine; Antifungal; Dermatology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006154243,0.0004796924,0.001770811,0.0003428874,0.0001547048,0.00008670241,0.0002690814,0.000120327,0.000106699],"category_scores_gemma":[0.003593515,0.0003680991,0.0002505233,0.0005151498,0.0002613649,0.0005221943,0.0003634865,0.0002348124,0.00001844591],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002981653,"about_ca_system_score_gemma":0.0005715624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001056053,"about_ca_topic_score_gemma":0.003843454,"domain_scores_codex":[0.9965879,0.000352697,0.00100439,0.0007978393,0.0007039836,0.0005532322],"domain_scores_gemma":[0.9966072,0.001219491,0.0003730476,0.0006589533,0.0004571248,0.0006841518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4884754,0.004503504,0.5058702,0.00009032971,0.0001416688,0.00000482544,0.0001140601,0.00003315224,0.000002574421,0.00009457369,0.00003054885,0.0006391046],"study_design_scores_gemma":[0.5045456,0.002441314,0.4920363,0.0002091063,0.0003406539,6.595516e-8,0.00004833257,0.00001991471,0.00004016021,0.00008081808,0.00001041015,0.0002273106],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867297,0.00005538139,0.00002126736,0.000198241,0.0002879112,0.01137859,0.0002427673,0.00002589077,0.001060187],"genre_scores_gemma":[0.998469,0.00006267474,0.00002318791,0.0003844395,0.00003157609,0.0006209972,0.0003290111,0.0000429105,0.00003621548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01607017,"threshold_uncertainty_score":0.9998771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01811370189429643,"score_gpt":0.319837989000212,"score_spread":0.3017242871059155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}