{"id":"W164894659","doi":"10.1093/ofid/ofu051.99","title":"1211A Phase 3, Randomized, Double-Blind, Non-Inferiority Trial to Evaluate Efficacy and Safety of Isavuconazole versus Voriconazole in Patients with Invasive Mold Disease (SECURE): Outcomes in Invasive Aspergillosis Patients","year":2014,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; CancerCare Manitoba","funders":"","keywords":"Voriconazole; Medicine; Aspergillosis; Randomized controlled trial; Clinical trial; Internal medicine; Intensive care medicine; Antifungal; Dermatology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002740668,0.001830363,0.003316581,0.0004194199,0.0006483602,0.001632846,0.0007871066,0.002084703,0.01062541],"category_scores_gemma":[0.002593443,0.0006077674,0.001804247,0.0005447561,0.001237843,0.0009920095,0.0004605446,0.003436077,0.001722039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008507919,"about_ca_system_score_gemma":0.001908784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004136168,"about_ca_topic_score_gemma":0.001159489,"domain_scores_codex":[0.9985914,0.0008289723,0.0001007706,0.0002086491,0.0001113212,0.000158875],"domain_scores_gemma":[0.998372,0.0004626491,0.0004155941,0.0001232773,0.0001321622,0.0004944064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9804617,0.004088913,0.0006311266,0.0006025196,0.0006339821,0.00003776157,0.00003424274,0.0002239052,0.00260463,0.0001647356,0.001329123,0.009187349],"study_design_scores_gemma":[0.9549689,0.04226591,0.001171829,0.00003101613,0.0002608158,0.00003408161,0.000009539705,0.0002997124,0.0001787042,0.0001661036,0.0006028136,0.00001052268],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9611875,0.009029679,0.001429574,0.001971818,0.001036842,0.01309148,0.004302145,0.0002168934,0.007734093],"genre_scores_gemma":[0.965279,0.00300229,0.002980475,0.002419117,0.0009067397,0.01605663,0.004739645,0.00004871971,0.004567367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01062541,"threshold_uncertainty_score":0.03554559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01811370189429643,"score_gpt":0.319837989000212,"score_spread":0.3017242871059155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}