{"id":"W1651484967","doi":"10.4049/jimmunol.182.2.948","title":"A Dual Role for Talin in NK Cell Cytotoxicity: Activation of LFA-1-Mediated Cell Adhesion and Polarization of NK Cells","year":2009,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Terry Fox Research Institute; BC Cancer Agency","funders":"Jiangsu National Synergistic Innovation Center for Advanced Materials; Wellcome Trust","keywords":"Cell biology; NKG2D; Janus kinase 3; Lymphocyte function-associated antigen 1; Interleukin 21; Cytotoxicity; Cytotoxic T cell; Lymphokine-activated killer cell; CD49b; Natural killer cell; Cell adhesion; Biology; Chemistry; Cell; Cell adhesion molecule; In vitro; Intercellular Adhesion Molecule-1; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001824611,0.0005510427,0.0002842487,0.0002549916,0.0004389807,0.0008314747,0.0003118199,0.0004982312,0.001562128],"category_scores_gemma":[0.0001398953,0.0001228278,0.0002297254,0.0001233216,0.0003991259,0.0006653998,0.0006208006,0.0006337756,0.0003971044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005145682,"about_ca_system_score_gemma":0.0002473357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001902669,"about_ca_topic_score_gemma":0.0002420689,"domain_scores_codex":[0.9997877,0.00002986595,0.00001615732,0.00004448605,0.00006165507,0.00006008221],"domain_scores_gemma":[0.9998543,0.00001839668,0.00003591362,0.00001562686,0.00001848974,0.00005728651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005965571,0.00001091175,0.0002277596,0.00003942055,0.000002680093,0.0001127692,0.00001677343,0.00006011437,0.9976164,0.0004940308,0.00002121042,0.001338086],"study_design_scores_gemma":[0.00001377775,0.00006852484,0.002641644,0.000006354526,0.00001487113,0.0006663353,0.00003501101,0.000799366,0.9936666,0.0001810534,0.001901999,0.000004426505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876875,0.001817193,0.008244185,0.0002316326,0.00003371859,0.00001564761,0.0001029864,0.00007770996,0.001789476],"genre_scores_gemma":[0.9946732,0.0004299068,0.002031756,0.00004569066,0.00001286144,0.0000171652,0.0001151664,0.000009526733,0.002664875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001562128,"threshold_uncertainty_score":0.005225778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0123789836658356,"score_gpt":0.2677697956216634,"score_spread":0.2553908119558278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}