{"id":"W1651484967","doi":"10.4049/jimmunol.182.2.948","title":"A Dual Role for Talin in NK Cell Cytotoxicity: Activation of LFA-1-Mediated Cell Adhesion and Polarization of NK Cells","year":2009,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Terry Fox Research Institute; BC Cancer Agency","funders":"Jiangsu National Synergistic Innovation Center for Advanced Materials; Wellcome Trust","keywords":"Cell biology; NKG2D; Janus kinase 3; Lymphocyte function-associated antigen 1; Interleukin 21; Cytotoxicity; Cytotoxic T cell; Lymphokine-activated killer cell; CD49b; Natural killer cell; Cell adhesion; Biology; Chemistry; Cell; Cell adhesion molecule; In vitro; Intercellular Adhesion Molecule-1; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007322571,0.0001002571,0.0003746994,0.0004007253,0.00002994644,0.000003548885,0.0001220123,0.000156468,0.00002934115],"category_scores_gemma":[0.0002503003,0.0000712551,0.00006938635,0.0002698858,0.0001008498,0.00007603196,0.00003900546,0.0003387724,0.000001731506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005852179,"about_ca_system_score_gemma":0.000133027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004135143,"about_ca_topic_score_gemma":0.000002453273,"domain_scores_codex":[0.9986438,0.0002297358,0.0006099463,0.00008534636,0.000248933,0.0001822705],"domain_scores_gemma":[0.9984882,0.0004079111,0.0005733864,0.0001638212,0.0003237289,0.00004298213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002908302,0.0003905607,0.0005276062,0.00008289978,0.00002233237,0.000005313897,0.0006484203,0.00003964081,0.9940757,0.00001201857,0.00005061414,0.001236563],"study_design_scores_gemma":[0.00339493,0.003309734,0.02007042,0.0001163718,0.00004650187,0.00004432565,0.0006043304,0.0005222632,0.971588,0.0001909683,0.00006161706,0.00005055861],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971324,0.001040526,0.0007002432,0.0005760214,0.00003179764,0.0003782973,0.000005170979,0.000003090946,0.0001324517],"genre_scores_gemma":[0.9982981,0.0008706701,0.0005590694,0.00008011291,0.00003105986,0.000001129796,0.000009493268,0.00001184166,0.0001385083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02248775,"threshold_uncertainty_score":0.2905699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0123789836658356,"score_gpt":0.2677697956216634,"score_spread":0.2553908119558278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}