{"id":"W1656025217","doi":"10.1111/j.1600-6143.2012.04124.x","title":"Antibody Mediated Rejection Associated With Complement Factor H–Related Protein 3/1 Deficiency Successfully Treated With Eculizumab","year":2012,"lang":"en","type":"article","venue":"American Journal of Transplantation","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":65,"is_retracted":false,"has_abstract":false,"ca_institutions":"London Health Sciences Centre; Western University; University of Toronto; Toronto General Hospital; University Health Network; SickKids Foundation; Hospital for Sick Children","funders":"","keywords":"Eculizumab; Atypical hemolytic uremic syndrome; Medicine; Thrombotic microangiopathy; Immunology; Complement system; Plasmapheresis; Factor H; Alternative complement pathway; Complement component 5; Complement membrane attack complex; Antibody; Complement factor B; Complement factor I; Autoantibody; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000268333,0.0002190382,0.0004126808,0.0002457284,0.0001553421,0.00001816638,0.0001527271,0.00005303929,0.0003458868],"category_scores_gemma":[0.00002771924,0.0001512258,0.00007336401,0.0004784841,0.0002208234,0.0003448541,0.000004837697,0.0002064505,0.00002299301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001374863,"about_ca_system_score_gemma":0.0001068694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000216248,"about_ca_topic_score_gemma":0.00007057849,"domain_scores_codex":[0.9981892,0.0004906378,0.0006047335,0.0001544867,0.0001743923,0.0003865119],"domain_scores_gemma":[0.9982839,0.0001587751,0.001098726,0.0001154938,0.0002753387,0.00006778352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002965609,0.0007161705,0.5942687,0.00005144688,0.0008619374,0.00004304056,0.002318971,0.00008498931,0.3972443,0.00006867571,0.00002323835,0.001352896],"study_design_scores_gemma":[0.007210214,0.005584456,0.9437662,0.0008001658,0.0007430905,0.00090824,0.002230903,0.000008951069,0.03821955,0.000005863837,0.0001181712,0.0004042301],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950576,0.0003122926,0.003645872,0.00006108397,0.0001051789,0.0004621106,0.0001548908,0.00005381368,0.000147178],"genre_scores_gemma":[0.9988566,0.00003158387,0.0001309844,0.00001910395,0.00001442749,0.00001497368,0.0008814099,0.00002263435,0.00002825733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3590248,"threshold_uncertainty_score":0.616681,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009962172710309667,"score_gpt":0.2535815157363349,"score_spread":0.2436193430260253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}