{"id":"W1656644461","doi":"10.1038/35053086","title":"CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling","year":2001,"lang":"en","type":"article","venue":"Nature","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":564,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Heart and Stroke Foundation; University of Toronto; University Health Network; Amgen (Canada); Ontario Institute for Cancer Research","funders":"National Institutes of Health; U.S. Department of Agriculture","keywords":"Cell biology; Cytokine receptor; Protein tyrosine phosphatase; Janus kinase; JAK-STAT signaling pathway; Biology; Receptor tyrosine kinase; Tyrosine kinase 2; Tyrosine phosphorylation; Tyrosine kinase; Proto-oncogene tyrosine-protein kinase Src; Janus kinase 2; Signal transduction; SH2 domain; Receptor; Platelet-derived growth factor receptor; Biochemistry; Growth factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00009906849,0.0001650281,0.0002291896,0.00009787869,0.0001200744,0.000035939,0.00005750444,0.0004045323,0.001639265],"category_scores_gemma":[0.0001501956,0.0001334399,0.000084004,0.0002300338,0.00004896502,0.0001266575,0.00003011982,0.001370741,0.00005413421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004155565,"about_ca_system_score_gemma":0.00004164055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003187721,"about_ca_topic_score_gemma":0.000004033543,"domain_scores_codex":[0.9990936,0.00001571354,0.0001852112,0.000293309,0.0002056721,0.0002065152],"domain_scores_gemma":[0.9993625,0.0000787153,0.00007319471,0.0001732972,0.0001636527,0.0001486112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009212829,0.0002675392,0.002861539,0.00009215504,0.0001761718,0.0002016744,0.0008362139,0.000009545113,0.7855378,0.001150348,0.1951212,0.01282456],"study_design_scores_gemma":[0.001380686,0.0002882219,0.002177501,0.0002862254,0.00009340229,0.0003045324,0.0001333845,0.0007106503,0.5682603,0.0003480271,0.4258215,0.0001955802],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980754,0.006699543,0.0001256,0.00914923,0.0003085457,0.0002971589,0.0001798733,0.0001235259,0.002362509],"genre_scores_gemma":[0.9919584,0.0003506438,0.001400222,0.003427638,0.0004432093,0.000008938819,0.0001241328,0.00002621806,0.002260548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2307003,"threshold_uncertainty_score":0.9992734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0144892396541192,"score_gpt":0.2803790157887213,"score_spread":0.2658897761346021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}