{"id":"W1656644461","doi":"10.1038/35053086","title":"CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling","year":2001,"lang":"en","type":"article","venue":"Nature","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":564,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Heart and Stroke Foundation; University of Toronto; University Health Network; Amgen (Canada); Ontario Institute for Cancer Research","funders":"National Institutes of Health; U.S. Department of Agriculture","keywords":"Cell biology; Cytokine receptor; Protein tyrosine phosphatase; Janus kinase; JAK-STAT signaling pathway; Biology; Receptor tyrosine kinase; Tyrosine kinase 2; Tyrosine phosphorylation; Tyrosine kinase; Proto-oncogene tyrosine-protein kinase Src; Janus kinase 2; Signal transduction; SH2 domain; Receptor; Platelet-derived growth factor receptor; Biochemistry; Growth factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002172747,0.0003442549,0.0001902318,0.0003878651,0.000347992,0.001079353,0.000205038,0.0003351108,0.001993085],"category_scores_gemma":[0.0003816005,0.0002369563,0.0002395256,0.0001684401,0.0002783657,0.0003650377,0.0004829077,0.0007008964,0.0008852552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005513968,"about_ca_system_score_gemma":0.0002640835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003707448,"about_ca_topic_score_gemma":0.000559998,"domain_scores_codex":[0.9995767,0.00008312227,0.00001923124,0.00006499334,0.0001236803,0.0001322491],"domain_scores_gemma":[0.9998363,0.00002464946,0.00003995892,0.00001349538,0.00002104184,0.00006443218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002201736,0.00003530928,0.001586619,0.00005806877,0.00001393676,0.0002448851,0.00002528183,0.0001240664,0.9818026,0.002160193,0.0006437268,0.01308514],"study_design_scores_gemma":[0.00005975371,0.0001834377,0.01908439,0.00002313495,0.00003593803,0.002065943,0.00007549587,0.002368717,0.9505932,0.00119199,0.02430464,0.00001334201],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.937211,0.02897525,0.011287,0.001577833,0.0005134108,0.00006166399,0.0002691282,0.0003034904,0.01980128],"genre_scores_gemma":[0.9900575,0.002935658,0.001312672,0.0001583944,0.00009306167,0.00001498757,0.0001538986,0.000024253,0.005249617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001993085,"threshold_uncertainty_score":0.006667554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0144892396541192,"score_gpt":0.2803790157887213,"score_spread":0.2658897761346021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}