{"id":"W1658415972","doi":"10.1111/j.1742-4658.2010.07775.x","title":"Proteolysis of <i>Pseudomonas</i> exotoxin A within hepatic endosomes by cathepsins B and D produces fragments displaying <i>in vitro</i> ADP‐ribosylating and apoptotic effects","year":2010,"lang":"en","type":"article","venue":"FEBS Journal","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"McGill University","keywords":"Endosome; In vivo; Cathepsin B; Cathepsin; Cathepsin D; Cell biology; Pseudomonas exotoxin; Biology; Caspase; Endocytosis; Molecular biology; Biochemistry; In vitro; Cytosol; Cytochrome c; Programmed cell death; Chemistry; Apoptosis; Cytotoxicity; Intracellular; Cell; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001682735,0.0003472953,0.0001476664,0.0001115187,0.00008289919,0.0002556311,0.00009800935,0.0001942785,0.0004713509],"category_scores_gemma":[0.0001547529,0.0001314207,0.000298065,0.00009855518,0.000180398,0.0002278006,0.0001259744,0.0003021888,0.0002323337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003252792,"about_ca_system_score_gemma":0.0001473275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005888902,"about_ca_topic_score_gemma":0.0005490344,"domain_scores_codex":[0.9998837,0.00002104558,0.00001333678,0.00002092243,0.0000244889,0.00003652589],"domain_scores_gemma":[0.9998538,0.00002804219,0.0000570964,0.00002427493,0.00001406567,0.00002262394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008595677,0.00001112947,0.0002194491,0.00001207016,0.000002927611,0.00003625221,0.000006588445,0.00003236205,0.9992676,0.00002534102,0.000004396303,0.0002958914],"study_design_scores_gemma":[0.000004659721,0.0001658215,0.001991977,0.000001346684,0.000005597032,0.0001675079,0.00001147438,0.0002578924,0.9971917,0.00001161028,0.0001888274,0.000001574998],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964876,0.0004700992,0.002422781,0.0000222889,0.00000528631,0.00001364361,0.0001120503,0.00002297131,0.000443234],"genre_scores_gemma":[0.9968663,0.0003793814,0.001806484,0.00001707645,0.000002934547,0.00001093367,0.0002769062,0.000009574538,0.0006303206],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005888902,"threshold_uncertainty_score":0.002360046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004151731200813641,"score_gpt":0.2069814256204553,"score_spread":0.2028296944196417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}