{"id":"W1658415972","doi":"10.1111/j.1742-4658.2010.07775.x","title":"Proteolysis of <i>Pseudomonas</i> exotoxin A within hepatic endosomes by cathepsins B and D produces fragments displaying <i>in vitro</i> ADP‐ribosylating and apoptotic effects","year":2010,"lang":"en","type":"article","venue":"FEBS Journal","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"McGill University","keywords":"Endosome; In vivo; Cathepsin B; Cathepsin; Cathepsin D; Cell biology; Pseudomonas exotoxin; Biology; Caspase; Endocytosis; Molecular biology; Biochemistry; In vitro; Cytosol; Cytochrome c; Programmed cell death; Chemistry; Apoptosis; Cytotoxicity; Intracellular; Cell; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007444053,0.0002656165,0.0005189446,0.0001881009,0.000329782,0.00006704492,0.0001936027,0.0002199112,0.00003497536],"category_scores_gemma":[0.0003028451,0.0002219408,0.0000752981,0.0001562101,0.0002113935,0.000268951,0.0001160145,0.001013082,0.000006266533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002080347,"about_ca_system_score_gemma":0.00005482576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008918797,"about_ca_topic_score_gemma":0.00002988816,"domain_scores_codex":[0.998305,0.000245415,0.000582075,0.0003405178,0.00009179998,0.0004351424],"domain_scores_gemma":[0.9990233,0.0002024446,0.0004518667,0.0002141589,0.00004698598,0.0000612878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001514262,0.0001703888,0.006303181,0.0001116828,0.0001101195,0.0000125692,0.00156055,0.000001604264,0.9860024,0.00003850449,0.00003000651,0.005507548],"study_design_scores_gemma":[0.002200338,0.0002752444,0.004802268,0.0002304945,0.00007314196,0.0005691617,0.0002556803,0.00003581388,0.9908701,0.0003657573,0.00009106424,0.0002309419],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954585,0.002978707,0.0001893945,0.0001050137,0.0006393259,0.000555374,0.00002040222,0.00001872996,0.00003453313],"genre_scores_gemma":[0.9973772,0.0001732649,0.002097952,0.00006933702,0.00003922716,0.00004496058,0.00001200492,0.00002946029,0.0001565688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005276606,"threshold_uncertainty_score":0.9050485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004151731200813641,"score_gpt":0.2069814256204553,"score_spread":0.2028296944196417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}