{"id":"W1659248918","doi":"10.4049/jimmunol.168.10.5170","title":"Kinetic Analysis of a Unique Direct Prothrombinase, <i>fgl2</i> , and Identification of a Serine Residue Critical for the Prothrombinase Activity","year":2002,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of Toronto; Toronto General Hospital","funders":"","keywords":"Prothrombinase; Chemistry; Thrombin; Serine protease; Biochemistry; Serine; Thrombomodulin; Molecular biology; Enzyme; Protease; Biology; Immunology; Platelet","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001867795,0.000365003,0.0001816738,0.0001057359,0.0001001984,0.0003351354,0.0002139294,0.0002599201,0.0005158807],"category_scores_gemma":[0.000282341,0.0000915688,0.0002178026,0.0001677808,0.0001883896,0.0002384251,0.00008437069,0.0003287807,0.0002130177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005884711,"about_ca_system_score_gemma":0.0001660641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001258821,"about_ca_topic_score_gemma":0.0006586742,"domain_scores_codex":[0.9998903,0.00002233234,0.000008416126,0.00002793026,0.00002991514,0.00002101828],"domain_scores_gemma":[0.9999123,0.00002107127,0.00002553914,0.000009126665,0.00001800591,0.00001399433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000163751,0.00001574247,0.0006475433,0.00003818824,0.00001083322,0.00005030293,0.00002027143,0.0003136048,0.9971929,0.0002334569,0.0000521732,0.001261164],"study_design_scores_gemma":[0.000008404082,0.00006453253,0.002302731,0.000002640651,0.000009003152,0.0002319162,0.000009672099,0.004993984,0.9912772,0.00003680104,0.001057484,0.000005681418],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877082,0.001478843,0.009327366,0.00006697076,0.00001596251,0.00002318086,0.0003803237,0.00005641257,0.0009426897],"genre_scores_gemma":[0.994092,0.0003349548,0.004083314,0.0000146701,0.000005511506,0.00001411297,0.0006461469,0.00001476839,0.0007944669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001258821,"threshold_uncertainty_score":0.004269719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03121405002197614,"score_gpt":0.3020109401341634,"score_spread":0.2707968901121873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}