{"id":"W1663597622","doi":"10.3389/fncel.2015.00289","title":"Gene expression profiling for human iPS-derived motor neurons from sporadic ALS patients reveals a strong association between mitochondrial functions and neurodegeneration","year":2015,"lang":"en","type":"article","venue":"Frontiers in Cellular Neuroscience","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Brock University; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Universidade de São Paulo; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Neurodegeneration; Biology; Amyotrophic lateral sclerosis; Motor neuron; Induced pluripotent stem cell; Frontotemporal dementia; Neuroscience; Genetics; Cell biology; Gene; Disease; Medicine; Dementia; Embryonic stem cell; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009348193,0.0002112104,0.000321737,0.0004670651,0.000152794,0.0002298087,0.00007370744,0.0001799586,0.00118184],"category_scores_gemma":[0.0001059174,0.00004782149,0.0003002635,0.0006248832,0.0001100186,0.00006030513,0.0001153657,0.000240616,0.0004636653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008210616,"about_ca_system_score_gemma":0.0001191943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003082117,"about_ca_topic_score_gemma":0.0003842633,"domain_scores_codex":[0.9999125,0.000004517628,0.000008639053,0.000029213,0.00002822938,0.00001693352],"domain_scores_gemma":[0.999957,0.00001111194,0.00000912033,0.000004188849,0.00001143873,0.000007162037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003664532,0.00003235442,0.01119729,0.0001622487,0.00005047102,0.0003766799,0.0001117608,0.0002577458,0.9768449,0.00009037645,0.0003552686,0.01015438],"study_design_scores_gemma":[0.00003336833,0.0007032414,0.4803063,0.00009540192,0.0003572535,0.004142225,0.0006543932,0.003418887,0.4932349,0.000490216,0.01653111,0.0000325196],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810268,0.001798406,0.00318357,0.00007905951,0.0000292238,0.00002751513,0.0124096,0.0001025688,0.001343317],"genre_scores_gemma":[0.9622399,0.002287018,0.00614717,0.0001745028,0.00001984153,0.0001572989,0.02581989,0.00004226538,0.003112109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00118184,"threshold_uncertainty_score":0.003953636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05670935276383876,"score_gpt":0.2882508239612084,"score_spread":0.2315414711973696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}