{"id":"W1664505274","doi":"10.1007/s100480100123","title":"Mutations in the open reading frame of the β-site APP cleaving enzyme (BACE) locus are not a common cause of Alzheimer's disease","year":2001,"lang":"en","type":"article","venue":"Neurogenetics","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"Surrey Place Centre; University of Toronto; University Health Network","funders":"National Institute on Aging; U.S. Public Health Service","keywords":"Open reading frame; Genetics; Biology; Locus (genetics); Gene; Amyloid precursor protein; Allele; Pathogenesis; Alzheimer's disease; Coding region; Disease; Peptide sequence; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004425845,0.0008282887,0.0007793396,0.001671898,0.0006965466,0.000499974,0.0005230555,0.00182065,0.003202101],"category_scores_gemma":[0.002716246,0.0003125959,0.0004198402,0.0006295647,0.0010546,0.0004691969,0.0005091538,0.001052166,0.0009445008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001811626,"about_ca_system_score_gemma":0.0001885186,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003520882,"about_ca_topic_score_gemma":0.0004458848,"domain_scores_codex":[0.9992954,0.0001040947,0.0001361415,0.0001886218,0.0001889376,0.00008687095],"domain_scores_gemma":[0.9982834,0.0006730162,0.0004994173,0.0001875086,0.0001238622,0.0002328103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00317165,0.0005988584,0.0982906,0.0002835333,0.0003876461,0.1146114,0.001239789,0.000361708,0.7497963,0.005701157,0.001622094,0.02393517],"study_design_scores_gemma":[0.0007171181,0.001306638,0.435833,0.0002023915,0.0008392388,0.3920984,0.0007833125,0.00145045,0.1436585,0.006408083,0.01654764,0.0001551627],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949911,0.0009021763,0.001310847,0.0002784035,0.0001630899,0.000016132,0.0002699754,0.00006203479,0.00200619],"genre_scores_gemma":[0.9975526,0.0003502655,0.0006267727,0.0001078576,0.0001301546,0.00000932097,0.0002918929,0.00002897588,0.0009022949],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003202101,"threshold_uncertainty_score":0.01071215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06310191869045047,"score_gpt":0.3486466815939777,"score_spread":0.2855447629035272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}