{"id":"W1664996601","doi":"10.4049/jimmunol.1003597","title":"Caspase-1–Processed Cytokines IL-1β and IL-18 Promote IL-17 Production by γδ and CD4 T Cells That Mediate Autoimmunity","year":2011,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":341,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"Irish Research Council; Science Foundation Ireland; Health Research Board","keywords":"Experimental autoimmune encephalomyelitis; Inflammasome; Immunology; Caspase 1; Interleukin 12; Autoimmunity; Interleukin 17; Interleukin; T cell; Biology; Cytokine; Cytotoxic T cell; Inflammation; Immune system; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006571696,0.0002079755,0.0002694047,0.00007369694,0.0002045965,0.00002104157,0.0003080604,0.0001943057,0.00003074196],"category_scores_gemma":[0.0001056265,0.0001450785,0.00006008336,0.00007801956,0.0004655551,0.00003316131,0.0001622728,0.000331633,0.000003510667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001015396,"about_ca_system_score_gemma":0.00007640407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006141426,"about_ca_topic_score_gemma":0.00001367353,"domain_scores_codex":[0.9988945,0.0002038226,0.0003495245,0.000170525,0.0001027875,0.0002788368],"domain_scores_gemma":[0.9989871,0.00001680328,0.000428762,0.0003260848,0.0002003403,0.0000409385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006434972,0.00008011994,0.0002222619,0.00002332115,0.0002281222,0.000004616982,0.00127141,0.000001660051,0.9918761,0.000003725852,0.00165084,0.003994376],"study_design_scores_gemma":[0.000900281,0.001021178,0.006093837,0.00002542026,0.0001048441,0.000525581,0.001109978,0.000003906051,0.9732348,0.0002323476,0.01656039,0.0001873878],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894049,0.00922569,0.00004803613,0.0004955422,0.0003781411,0.0001641948,0.0000150615,0.000007625224,0.0002608635],"genre_scores_gemma":[0.9859439,0.01317819,0.0001177039,0.0001265841,0.00009072613,0.0000045006,0.00001799326,0.0000234035,0.0004969885],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01864119,"threshold_uncertainty_score":0.591613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01373252813189039,"score_gpt":0.2150011025369827,"score_spread":0.2012685744050923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}