{"id":"W1664996601","doi":"10.4049/jimmunol.1003597","title":"Caspase-1–Processed Cytokines IL-1β and IL-18 Promote IL-17 Production by γδ and CD4 T Cells That Mediate Autoimmunity","year":2011,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":341,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"Irish Research Council; Science Foundation Ireland; Health Research Board","keywords":"Experimental autoimmune encephalomyelitis; Inflammasome; Immunology; Caspase 1; Interleukin 12; Autoimmunity; Interleukin 17; Interleukin; T cell; Biology; Cytokine; Cytotoxic T cell; Inflammation; Immune system; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002099417,0.0007732346,0.0003755692,0.0004987735,0.0001801056,0.0005619967,0.0001621583,0.0003591197,0.002054835],"category_scores_gemma":[0.0002153369,0.0002113527,0.000450116,0.0002624847,0.0002821632,0.0003924415,0.0002953291,0.001158667,0.0006881557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002614175,"about_ca_system_score_gemma":0.0003064969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001332176,"about_ca_topic_score_gemma":0.000212528,"domain_scores_codex":[0.9996724,0.00005504433,0.00004722424,0.00005445074,0.00007701843,0.00009387451],"domain_scores_gemma":[0.999779,0.00002376559,0.00007807008,0.0000288818,0.00003380149,0.00005639702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002734838,0.00009208648,0.0007658498,0.0001299745,0.000009901966,0.0001263496,0.00004296852,0.0001582866,0.993962,0.0001937202,0.0001063626,0.004138943],"study_design_scores_gemma":[0.0001957874,0.0008901959,0.009084008,0.00007255807,0.00005353853,0.0008123326,0.0001206708,0.001280338,0.9790742,0.0005100871,0.007894544,0.00001185381],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9786058,0.01013779,0.006297755,0.0002682621,0.0001907195,0.0001002918,0.0005110591,0.0001630662,0.003725264],"genre_scores_gemma":[0.9891032,0.004374519,0.003499439,0.0001522582,0.0001022199,0.00009082407,0.000313385,0.00002477651,0.002339364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002054835,"threshold_uncertainty_score":0.006874144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01373252813189039,"score_gpt":0.2150011025369827,"score_spread":0.2012685744050923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}