{"id":"W1665335542","doi":"10.3390/biology4030512","title":"Antibody Affinity Maturation in Fishes—Our Current Understanding","year":2015,"lang":"en","type":"review","venue":"Biology","topic":"Aquaculture disease management and microbiota","field":"Immunology and Microbiology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Somatic hypermutation; Biology; Cytidine deaminase; Affinity maturation; Antibody; Germinal center; Context (archaeology); Evolutionary biology; Zoology; Genetics; B cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003876215,0.0004575922,0.001345531,0.0003694147,0.0000846769,0.00002269119,0.0003871043,0.0008649192,0.0001414677],"category_scores_gemma":[0.00006464347,0.000346015,0.000287158,0.0002997518,0.00009188006,0.00006128302,0.0002366935,0.0006549886,0.001368286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003756509,"about_ca_system_score_gemma":0.0002037675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002070578,"about_ca_topic_score_gemma":0.00004082513,"domain_scores_codex":[0.9977219,0.0006340235,0.0005762726,0.000565507,0.00002006856,0.0004822193],"domain_scores_gemma":[0.999213,0.00005397875,0.0003416485,0.0003241396,0.00003628161,0.00003099437],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001646069,0.0004850966,0.0001170453,0.007371567,0.0007950345,0.00002943379,0.0002915644,1.933109e-7,0.0008125232,0.01351733,0.1080366,0.868379],"study_design_scores_gemma":[0.000473924,0.00004754653,0.00001337565,0.001351063,0.0003481542,0.00001985707,0.0001721002,9.127776e-8,0.000001875549,0.0003618012,0.996834,0.0003762445],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00001081572,0.9941499,0.000180244,0.00004398715,0.00274481,0.0007778942,0.0002313417,0.00007889334,0.001782132],"genre_scores_gemma":[0.0005556209,0.9789813,0.00001028268,0.00002550591,0.000135168,0.00004473775,0.01961994,0.00002857852,0.000598835],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8887974,"threshold_uncertainty_score":0.9998992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1865076573660282,"score_gpt":0.4183866543318477,"score_spread":0.2318789969658195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}