{"id":"W1667902581","doi":"10.1002/0471142735.im0217s103","title":"Single‐Domain Antibodies and Their Utility","year":2013,"lang":"en","type":"article","venue":"Current Protocols in Immunology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; University of Guelph; National Research Council Canada","funders":"","keywords":"Single-domain antibody; Antibody; Monoclonal antibody; Heavy chain; Immunogenicity; Computational biology; Epitope; Antigen; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005324355,0.0002261744,0.0002242859,0.0003389454,0.0001565387,0.0007312926,0.0004731002,0.0005185575,0.001918069],"category_scores_gemma":[0.000417426,0.0001542407,0.0001897704,0.0003067711,0.0004067328,0.0004764083,0.0003456901,0.0006594858,0.001026346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004201414,"about_ca_system_score_gemma":0.0002855653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002867417,"about_ca_topic_score_gemma":0.0002328404,"domain_scores_codex":[0.9997248,0.0000568496,0.00001329856,0.00005689147,0.0001186353,0.00002949341],"domain_scores_gemma":[0.999846,0.00004936519,0.00002241136,0.0000192274,0.00004092413,0.00002216672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002466406,0.00009363145,0.001105798,0.001198446,0.00003251053,0.0004140154,0.0001984417,0.001289553,0.5546222,0.03863969,0.00459624,0.3975629],"study_design_scores_gemma":[0.00003037394,0.0006676348,0.001836854,0.0002353447,0.00004678944,0.003160571,0.00007351751,0.002835181,0.4507796,0.01186089,0.5284423,0.00003081329],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2085227,0.5120777,0.1980987,0.004468956,0.001544443,0.0001866321,0.0006937914,0.000910229,0.07349687],"genre_scores_gemma":[0.7140685,0.1696374,0.08636579,0.001618431,0.0006249677,0.0002100772,0.0005746197,0.00008053532,0.02681963],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001918069,"threshold_uncertainty_score":0.006416619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07213346330826664,"score_gpt":0.3687266079278081,"score_spread":0.2965931446195414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}