{"id":"W1673881514","doi":"10.4049/jimmunol.174.3.1602","title":"Immune Activation of Type I IFNs by <i>Listeria monocytogenes</i> Occurs Independently of TLR4, TLR2, and Receptor Interacting Protein 2 but Involves TANK-Binding Kinase 1","year":2005,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Howard Hughes Medical Institute; U.S. Public Health Service; National Cancer Institute; National Institutes of Health; University of California, Los Angeles; University of Toronto","keywords":"TANK-binding kinase 1; TLR2; Signal transduction; Biology; Cell biology; TLR4; Kinase; Listeria monocytogenes; Intracellular; Protein kinase A; Intracellular parasite; MAP kinase kinase kinase; Bacteria; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001858809,0.0004107039,0.0002163707,0.0001678682,0.0001581617,0.0004211128,0.0001343027,0.0002663618,0.001660131],"category_scores_gemma":[0.0001609905,0.0001652598,0.0003873081,0.00007653004,0.0002114506,0.0002437554,0.0002744083,0.000496193,0.0007664257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004464281,"about_ca_system_score_gemma":0.0002224586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002140214,"about_ca_topic_score_gemma":0.0003081379,"domain_scores_codex":[0.9997484,0.0000451859,0.00002245885,0.0000453196,0.00004818458,0.00009055078],"domain_scores_gemma":[0.9998689,0.00001904043,0.00004863314,0.00002158107,0.00001593098,0.00002591038],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001855129,0.00001978768,0.0005165949,0.00002993241,0.000003536484,0.00004455516,0.000006014338,0.00002316662,0.9979261,0.00009204413,0.00005690193,0.001095932],"study_design_scores_gemma":[0.00004773114,0.0002978358,0.01342657,0.00001428391,0.00001809353,0.0006861611,0.00004133895,0.0007132504,0.9818991,0.0001828318,0.002666901,0.000005684055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924701,0.001549529,0.002148851,0.0001742406,0.00005274951,0.00001203666,0.0002137531,0.00008917721,0.003289571],"genre_scores_gemma":[0.9950604,0.0005438777,0.001853178,0.0001112088,0.0000240958,0.00001961197,0.0004337853,0.00001569958,0.001938122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001660131,"threshold_uncertainty_score":0.005553722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01531389450986389,"score_gpt":0.2467320415725303,"score_spread":0.2314181470626664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}