{"id":"W1673881514","doi":"10.4049/jimmunol.174.3.1602","title":"Immune Activation of Type I IFNs by <i>Listeria monocytogenes</i> Occurs Independently of TLR4, TLR2, and Receptor Interacting Protein 2 but Involves TANK-Binding Kinase 1","year":2005,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Howard Hughes Medical Institute; U.S. Public Health Service; National Cancer Institute; National Institutes of Health; University of California, Los Angeles; University of Toronto","keywords":"TANK-binding kinase 1; TLR2; Signal transduction; Biology; Cell biology; TLR4; Kinase; Listeria monocytogenes; Intracellular; Protein kinase A; Intracellular parasite; MAP kinase kinase kinase; Bacteria; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001105021,0.0001841778,0.0004883098,0.0002502706,0.0001416369,0.00001067161,0.000359658,0.0002683329,0.0001817748],"category_scores_gemma":[0.0004287966,0.0001371368,0.00009454922,0.0001701942,0.0003027492,0.0004249983,0.0001398557,0.0005223434,0.00002265709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007769188,"about_ca_system_score_gemma":0.0001083709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001226395,"about_ca_topic_score_gemma":0.000004414872,"domain_scores_codex":[0.9978229,0.0007250417,0.00103408,0.0001093602,0.00006757022,0.000240989],"domain_scores_gemma":[0.9972955,0.0003616024,0.001762653,0.0002469522,0.0003205706,0.00001271051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004233328,0.0001039357,0.0001612861,0.00002669349,0.0004237377,7.028578e-7,0.001863832,0.00001225608,0.9799901,0.00007485351,0.0002328107,0.01287648],"study_design_scores_gemma":[0.001473086,0.0008475914,0.001040541,0.0002403701,0.00006933507,0.0002025865,0.002731258,0.000003920538,0.9883966,0.00003222617,0.004846106,0.0001163524],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888313,0.00972344,0.0001002029,0.0005743414,0.0004643213,0.0002232599,0.0000100557,0.00000886448,0.00006425484],"genre_scores_gemma":[0.9983137,0.0009281813,0.0001574452,0.00002809182,0.00003749275,0.000002990797,0.00002809944,0.00001703497,0.0004870005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01276013,"threshold_uncertainty_score":0.5592278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01531389450986389,"score_gpt":0.2467320415725303,"score_spread":0.2314181470626664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}