{"id":"W1677866495","doi":"10.1007/s40261-015-0327-1","title":"Pharmacokinetic and Pharmacodynamic Comparison of Two Recombinant Human Erythropoietin Formulations, PDA10 and Eprex, in Healthy Korean Male Volunteers: A Randomized, Double-Blinded, Single-Dose, Two-Period Crossover Study","year":2015,"lang":"en","type":"article","venue":"Clinical Drug Investigation","topic":"Erythropoietin and Anemia Treatment","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Ministry of Health, British Columbia; NIH Clinical Center; Ajou University; Clinical Trial Center, China Medical University Hospital","keywords":"Medicine; Epoetin alfa; Pharmacokinetics; Crossover study; Pharmacodynamics; Bioequivalence; Erythropoietin; Confidence interval; Internal medicine; Pharmacology; Adverse effect; Area under the curve; Gastroenterology; Placebo","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001633953,0.001657855,0.003215168,0.0003350296,0.0005018148,0.0007588642,0.0007496775,0.001509874,0.003299231],"category_scores_gemma":[0.001834257,0.001320933,0.001179619,0.000378214,0.001608508,0.001441066,0.0004270243,0.002252975,0.0007575722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004549595,"about_ca_system_score_gemma":0.0009528415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006546492,"about_ca_topic_score_gemma":0.0007224315,"domain_scores_codex":[0.9990381,0.0004362882,0.00007938997,0.0002396798,0.00009452172,0.0001119412],"domain_scores_gemma":[0.9988176,0.0002667138,0.0002198127,0.0001623196,0.0001096402,0.0004238405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9360004,0.0264397,0.001331059,0.0003496068,0.000685371,0.00005872223,0.0001835519,0.0002482178,0.02277873,0.00006788428,0.000263996,0.0115928],"study_design_scores_gemma":[0.4164149,0.5559217,0.01777117,0.00002394085,0.001512988,0.0001699192,0.0001675962,0.001082459,0.005527739,0.0001377437,0.001169494,0.0001003831],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973823,0.0006993142,0.0005612231,0.00006294106,0.000104428,0.0006779269,0.0001920716,0.00003282349,0.0002868731],"genre_scores_gemma":[0.9949622,0.0007832755,0.001306804,0.0003369782,0.0001377213,0.0008852709,0.0003433724,0.00002457762,0.001219787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003299231,"threshold_uncertainty_score":0.01103705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1443688003860833,"score_gpt":0.4558119339915855,"score_spread":0.3114431336055022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}