{"id":"W1678695230","doi":"10.4049/jimmunol.0902207","title":"Soluble HIV Tat Protein Removes the IL-7 Receptor α-Chain from the Surface of Resting CD8 T Cells and Targets It for Degradation","year":2010,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Interleukin-7 receptor; Cell biology; Internalization; CD8; Endosome; T cell; Cell; Cytotoxic T cell; Biology; Cytoplasm; Cytosol; Downregulation and upregulation; Receptor; Endocytosis; Intracellular; Chemistry; Immune system; Biochemistry; IL-2 receptor; Immunology; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008180996,0.0003176944,0.0002716962,0.0001200119,0.0001967611,0.0003916843,0.0001478186,0.0003118,0.001540731],"category_scores_gemma":[0.0001451154,0.0001320765,0.0002727403,0.0001389565,0.0002231411,0.0002077188,0.0001691865,0.0004813007,0.0006671469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002166387,"about_ca_system_score_gemma":0.0002254548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003552701,"about_ca_topic_score_gemma":0.0004131333,"domain_scores_codex":[0.9998168,0.0000377372,0.0000145354,0.00003393513,0.00005873517,0.00003817101],"domain_scores_gemma":[0.9999245,0.00001474523,0.00002074573,0.00001652805,0.00001213733,0.0000112302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007009241,0.00001590922,0.0002568411,0.00003623151,0.000008465865,0.00005522776,0.00001797616,0.00005047157,0.9955694,0.0001969744,0.0001132156,0.003609105],"study_design_scores_gemma":[0.00002459526,0.0005102821,0.004283729,0.00001578534,0.00002448715,0.001096172,0.00004785978,0.001155374,0.98189,0.0001823799,0.01076351,0.000005993966],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9799298,0.007680074,0.009371207,0.0002545468,0.0001208875,0.00005731446,0.000406897,0.0001655589,0.002013576],"genre_scores_gemma":[0.9825503,0.003249551,0.007900939,0.0001391399,0.00004994422,0.00004764879,0.0009965631,0.00003323745,0.005032708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001540731,"threshold_uncertainty_score":0.005154252,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01606580950650243,"score_gpt":0.2487072959675833,"score_spread":0.2326414864610809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}