{"id":"W1679478585","doi":"10.4049/jimmunol.172.10.6418","title":"Attenuation of Experimental Autoimmune Encephalomyelitis and Nonimmune Demyelination by IFN-β plus Vitamin B12: Treatment to Modify Notch-1/Sonic Hedgehog Balance","year":2004,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Genomic variations and chromosomal abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Directorate for Biological Sciences; Hospital for Sick Children; Multiple Sclerosis Society; National Institute of Child Health and Human Development; Multiple Sclerosis Society of Canada","keywords":"Experimental autoimmune encephalomyelitis; Multiple sclerosis; Remyelination; Sonic hedgehog; Medicine; In vivo; Encephalomyelitis; Myelin; Immunology; Oligodendrocyte; Biology; Internal medicine; Central nervous system; Signal transduction; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002002226,0.0001272332,0.0002153309,0.00005207541,0.00009759591,0.000008804426,0.0001717901,0.00009501345,0.00001444258],"category_scores_gemma":[0.00002367999,0.00009560403,0.00006328114,0.00006054399,0.000113912,0.00001277062,0.00007179275,0.00007287945,0.000003652618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001351335,"about_ca_system_score_gemma":0.0001242043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001585946,"about_ca_topic_score_gemma":0.00001302347,"domain_scores_codex":[0.9991596,0.00009254886,0.0003969359,0.0001046489,0.00008718413,0.0001590595],"domain_scores_gemma":[0.9993455,0.00002068076,0.0002942255,0.0001905539,0.0001207923,0.00002821032],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002505473,0.00009164651,0.0001032747,0.00000359358,0.0001301361,0.000001125105,0.001831036,0.0007909405,0.9946931,0.00018208,0.0000416204,0.001880923],"study_design_scores_gemma":[0.003054124,0.003242306,0.02479235,0.00004073115,0.00006215458,0.0003708216,0.002180613,0.00003616765,0.9636961,0.0001235421,0.002247095,0.0001540255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857593,0.01057288,0.002507591,0.0007543626,0.000189246,0.0001364193,0.00002023151,0.000002717193,0.00005721502],"genre_scores_gemma":[0.997451,0.001406423,0.0006821482,0.00005950994,0.0000669467,0.000008885407,0.0000251273,0.00001061805,0.0002893361],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03099701,"threshold_uncertainty_score":0.3898619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006895543233453629,"score_gpt":0.2303391661330354,"score_spread":0.2234436228995818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}