{"id":"W1687303282","doi":"10.1177/135965350601100208","title":"Evolution of Transmitted HIV-1 with Drug-Resistance Mutations in the Absence of Therapy: Effects on Cd4 <sup>+</sup> T-Cell Count and HIV-1 Rna Load","year":2006,"lang":"en","type":"article","venue":"Antiviral Therapy","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Hip and Knee Clinic","funders":"","keywords":"Biology; Reverse transcriptase; Drug resistance; Virology; Seroconversion; Mutation; Interquartile range; Population; Wild type; Virus; Viral load; Genetics; Gene; Medicine; Internal medicine; RNA; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004501873,0.000234534,0.0002645131,0.0002727778,0.0002030799,0.0003246435,0.0001460842,0.0002263795,0.0009714942],"category_scores_gemma":[0.00238967,0.0001550171,0.0001639111,0.0002053971,0.0002185999,0.0002167548,0.0001867881,0.0003033954,0.0001242513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003908003,"about_ca_system_score_gemma":0.0001780496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001402594,"about_ca_topic_score_gemma":0.001786938,"domain_scores_codex":[0.9996794,0.0001202824,0.000019014,0.00005141851,0.00006416547,0.00006567759],"domain_scores_gemma":[0.9987988,0.0004648257,0.0003321736,0.00006928406,0.00007340908,0.0002613836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009252802,0.0007026473,0.8591444,0.00009155736,0.0001830516,0.001879498,0.0004010005,0.001480423,0.09120164,0.0001212007,0.0002349837,0.03530686],"study_design_scores_gemma":[0.0001069111,0.005293516,0.9827456,0.00001194397,0.00008752556,0.003187109,0.00007351409,0.001833229,0.006274707,0.00005846623,0.0003110442,0.00001634423],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999727,0.0000856526,0.00001868643,0.000006599637,6.86523e-7,0.000002169013,0.00002178507,0.000001946808,0.000135444],"genre_scores_gemma":[0.9997262,0.00003940898,0.00005638189,0.000009180912,0.000004236218,0.000001820151,0.00007140973,0.000001686557,0.00008967829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001402594,"threshold_uncertainty_score":0.003250003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006189843537791374,"score_gpt":0.2233159166469177,"score_spread":0.2171260731091263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}