{"id":"W1691832734","doi":"10.1212/wnl.84.14_supplement.p7.199","title":"Safety and Tolerability Results of the Phase 2 Portion of the RADIANCE Trial: A Randomized, Double-blind, Placebo-controlled Trial of Oral RPC1063 in Relapsing Multiple Sclerosis (P7.199)","year":2015,"lang":"en","type":"article","venue":"Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"","keywords":"Tolerability; Placebo; Medicine; Multiple sclerosis; Double blind; Radiance; Randomized controlled trial; Internal medicine; Adverse effect; Pathology; Alternative medicine; Optics; Psychiatry; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002294534,0.001565732,0.002217771,0.0003036304,0.0004448288,0.0006207994,0.0006975846,0.001513561,0.005431356],"category_scores_gemma":[0.001566425,0.0005556266,0.001230427,0.0002847999,0.000847319,0.0007617082,0.0002404358,0.002331929,0.0009423062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003833793,"about_ca_system_score_gemma":0.0008310969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003233089,"about_ca_topic_score_gemma":0.0007973478,"domain_scores_codex":[0.9991934,0.0005098862,0.00005040653,0.00009376057,0.00007171787,0.00008084199],"domain_scores_gemma":[0.9990651,0.0002121991,0.0003171481,0.0000842021,0.0000809072,0.0002404741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9523447,0.01042063,0.0009957938,0.000506296,0.0008042767,0.00007402952,0.00005664743,0.0003390726,0.01221033,0.00007230084,0.001400361,0.02077565],"study_design_scores_gemma":[0.8516623,0.1407583,0.005037738,0.00002473496,0.0003748275,0.0000918959,0.00001461665,0.0002678403,0.001037646,0.0000628093,0.0006501123,0.00001718703],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905351,0.002363175,0.000589814,0.0003295447,0.0001195347,0.002878716,0.001283956,0.0001491185,0.001751075],"genre_scores_gemma":[0.9866215,0.001829347,0.001986873,0.0008027404,0.0003588901,0.003946028,0.002210687,0.00004800115,0.00219594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005431356,"threshold_uncertainty_score":0.0181697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.126928246439644,"score_gpt":0.3537307093554498,"score_spread":0.2268024629158058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}