{"id":"W1692011572","doi":"10.1046/j.1365-2958.2002.03115.x","title":"The tetracycline resistance protein Tet(○) perturbs the conformation of the ribosomal decoding centre","year":2002,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Heritage Foundation for Medical Research; Deutsche Forschungsgemeinschaft","keywords":"Tetracycline; Biology; Binding site; A-site; Elongation factor; Ribosome; Ribosomal RNA; Protein biosynthesis; Campylobacter jejuni; Protein subunit; Molecular biology; Biochemistry; RNA; Genetics; Bacteria; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003339038,0.000167965,0.0001364075,0.00001526257,0.0003585599,0.00002028051,0.0006244709,0.0001809848,0.0000486577],"category_scores_gemma":[0.0002757663,0.00008448341,0.0001664556,0.00009806437,0.0002769197,0.000003623813,0.0001592276,0.0001381477,0.00002020987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001259171,"about_ca_system_score_gemma":0.00002260908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004471117,"about_ca_topic_score_gemma":0.00004761752,"domain_scores_codex":[0.9987025,0.0003640414,0.0003211017,0.0002325092,0.00007552309,0.0003043071],"domain_scores_gemma":[0.9989502,0.00005015386,0.0002287063,0.0006516537,0.00009195377,0.00002735802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003549389,0.00001899391,0.00004172968,0.00001018216,0.00004185636,0.000001118835,0.00006673977,0.000007181954,0.9953024,0.001099744,0.001645134,0.001729384],"study_design_scores_gemma":[0.0002072317,0.00003927996,0.00004251974,0.00002163282,0.0000137237,0.00002141484,0.00006730481,0.00002537868,0.8308083,0.0001724521,0.1684801,0.000100567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9792106,0.007863161,0.002036852,0.006805785,0.0003085391,0.001038517,0.00004744598,0.0000127381,0.002676351],"genre_scores_gemma":[0.9953361,0.0001542381,0.000406805,0.0005722109,0.00006197542,0.00003531179,0.00001999228,0.0000181658,0.003395241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.166835,"threshold_uncertainty_score":0.3445134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005531693490511845,"score_gpt":0.186115541031564,"score_spread":0.1805838475410522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}