{"id":"W1692190376","doi":"10.2147/dddt.s84850","title":"Dolutegravir – a review of the pharmacology, efficacy, and safety in the treatment of HIV","year":2015,"lang":"en","type":"review","venue":"Drug Design Development and Therapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":153,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"","keywords":"Dolutegravir; Elvitegravir; Raltegravir; Integrase inhibitor; Tolerability; Medicine; Pharmacology; Adverse effect; Integrase; Drug; Human immunodeficiency virus (HIV); Virology; Antiretroviral therapy; Viral load","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004405326,0.0006565014,0.001187025,0.002231823,0.0002606977,0.0008173399,0.0005606685,0.0006005295,0.004296486],"category_scores_gemma":[0.0005612361,0.0002657515,0.0006251155,0.00222449,0.0002420615,0.0007970265,0.0004432738,0.001110228,0.001618354],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003577665,"about_ca_system_score_gemma":0.0009386234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001251212,"about_ca_topic_score_gemma":0.002608269,"domain_scores_codex":[0.9998295,0.0000307061,0.00003228152,0.00002487519,0.00006954213,0.00001303432],"domain_scores_gemma":[0.9997886,0.00009680822,0.00004195766,0.000004982583,0.00005093992,0.00001681903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007041933,0.00008759281,0.0001182281,0.03156152,0.0001347374,0.0001473319,0.00005442891,0.0002731613,0.001730606,0.001538809,0.02068584,0.9435973],"study_design_scores_gemma":[0.00002960726,0.0001735574,0.0008555058,0.005793043,0.0002949412,0.001453113,0.00004616664,0.0001245824,0.0006456662,0.0008459454,0.9897158,0.00002217513],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001658949,0.9986103,0.00008595669,0.0001277142,0.0000744517,0.000007343761,0.00003073682,0.000006428793,0.0008911645],"genre_scores_gemma":[0.0006679402,0.9985319,0.0001926138,0.00009516541,0.00005391248,0.000005449462,0.00003456749,0.000001133509,0.0004172923],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004296486,"threshold_uncertainty_score":0.01437318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09921393294740355,"score_gpt":0.3656776804598496,"score_spread":0.266463747512446,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}