{"id":"W1693243095","doi":"10.1002/stem.1944","title":"A Regulatory Network Involving β-Catenin, e-Cadherin, PI3k/Akt, and Slug Balances Self-Renewal and Differentiation of Human Pluripotent Stem Cells In Response to Wnt Signaling","year":2014,"lang":"en","type":"article","venue":"Stem Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Wnt signaling pathway; Biology; Cell biology; Catenin; Embryonic stem cell; PI3K/AKT/mTOR pathway; Stem cell; Cadherin; Protein kinase B; Induced pluripotent stem cell; Cellular differentiation; Signal transduction; Cell; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001026184,0.0002937722,0.0001642177,0.0002530823,0.0001266875,0.0004919748,0.0001575064,0.0001094473,0.0004824856],"category_scores_gemma":[0.00009174334,0.0002072865,0.000133192,0.0001247166,0.0001964885,0.0003349278,0.0002675114,0.0002212634,0.0001440265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003301899,"about_ca_system_score_gemma":0.0004143367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005691731,"about_ca_topic_score_gemma":0.0007387467,"domain_scores_codex":[0.9999046,0.00001390787,0.000008839923,0.00002784489,0.00002487082,0.00001986514],"domain_scores_gemma":[0.9999483,0.00000364322,0.00001667585,0.000003262534,0.000008578099,0.00001956214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008228613,0.00001199729,0.0008669406,0.00002621936,0.000005081557,0.00005339831,0.00002434999,0.00026799,0.9957081,0.0004520279,0.00003526775,0.002466287],"study_design_scores_gemma":[0.0000423819,0.0002431863,0.04225498,0.0000198682,0.00006624206,0.0002672765,0.0001264187,0.01496754,0.9377762,0.0006635913,0.003555905,0.00001635982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933943,0.001177785,0.003860114,0.00006429776,0.00001280066,0.00002391216,0.00009857528,0.0001056107,0.001262607],"genre_scores_gemma":[0.9968383,0.0005912994,0.001311205,0.00001843476,0.000005669943,0.00002357586,0.0001196356,0.000006135203,0.001085673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005691731,"threshold_uncertainty_score":0.002395749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01071556362567773,"score_gpt":0.2305695514457391,"score_spread":0.2198539878200614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}