{"id":"W1693243095","doi":"10.1002/stem.1944","title":"A Regulatory Network Involving β-Catenin, e-Cadherin, PI3k/Akt, and Slug Balances Self-Renewal and Differentiation of Human Pluripotent Stem Cells In Response to Wnt Signaling","year":2014,"lang":"en","type":"article","venue":"Stem Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Wnt signaling pathway; Biology; Cell biology; Catenin; Embryonic stem cell; PI3K/AKT/mTOR pathway; Stem cell; Cadherin; Protein kinase B; Induced pluripotent stem cell; Cellular differentiation; Signal transduction; Cell; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001326712,0.0002800718,0.0003909815,0.0001476282,0.0001282734,0.00006013886,0.0002402562,0.0002121404,0.000006599786],"category_scores_gemma":[0.000009383181,0.0002757446,0.00006786505,0.0001786379,0.0000866222,0.00001208408,0.0003653355,0.0001480106,0.000005060463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004940584,"about_ca_system_score_gemma":0.00005321488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004680282,"about_ca_topic_score_gemma":0.00008501,"domain_scores_codex":[0.9973873,0.000574741,0.0005247584,0.0006632388,0.0003371198,0.0005128519],"domain_scores_gemma":[0.9989953,0.0001039912,0.0002008529,0.0003753374,0.0001070591,0.000217476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000405998,0.00006779179,0.005952765,0.0002136496,0.00005035477,0.000004194348,0.0003327421,0.0008713841,0.99132,0.00002553562,0.0001422269,0.0006133488],"study_design_scores_gemma":[0.001067365,0.0008343671,0.007274242,0.0001942442,0.00002570621,0.000003949904,0.000206403,0.0005325482,0.988653,0.0000513103,0.0008238007,0.0003330752],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973769,0.001629857,0.0001761602,0.00004973364,0.0001468123,0.0005102781,0.00001110136,0.00002080476,0.00007831239],"genre_scores_gemma":[0.998427,0.0002429807,0.0003251036,0.00005125378,0.0001508241,0.00003042306,0.00001135149,0.00004124271,0.0007197774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002667021,"threshold_uncertainty_score":0.9999695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01071556362567773,"score_gpt":0.2305695514457391,"score_spread":0.2198539878200614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}