{"id":"W1695255415","doi":"10.1002/mc.22205","title":"Akt confers cisplatin chemoresistance in human gynecological carcinoma cells by modulating PPM1D stability","year":2014,"lang":"en","type":"article","venue":"Molecular Carcinogenesis","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Hôtel-Dieu de Québec; Ottawa Hospital; Université Laval; University of Ottawa","funders":"Ministry of Education, Science and Technology; National Research Foundation of Korea; Canadian Institutes of Health Research; National Research Foundation","keywords":"Cisplatin; Protein kinase B; Ovarian cancer; Cancer research; Biology; Cancer cell; Cancer; PI3K/AKT/mTOR pathway; Phosphorylation; Chemotherapy; Signal transduction; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000738209,0.0001602949,0.0001779113,0.0002489053,0.0001750213,0.0002382446,0.00009758746,0.000189067,0.001442063],"category_scores_gemma":[0.0000814497,0.0001526641,0.0001990497,0.0002667694,0.0001522275,0.0001058321,0.0001473143,0.0003302314,0.0003242664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002918218,"about_ca_system_score_gemma":0.0002313886,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001337572,"about_ca_topic_score_gemma":0.001454357,"domain_scores_codex":[0.999912,0.00001094701,0.00001334723,0.00001946372,0.00002221593,0.00002209303],"domain_scores_gemma":[0.9999688,0.000004899076,0.000007469599,0.000006414472,0.000003994891,0.000008353675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002871527,0.00006574109,0.00107644,0.00004495865,0.00000766509,0.0000755928,0.00003080867,0.00009613998,0.9963419,0.000171664,0.0001389028,0.001662944],"study_design_scores_gemma":[0.0001133299,0.0008109619,0.03453815,0.000009726013,0.0000374971,0.0008783877,0.00007582885,0.002165347,0.9551027,0.0001018502,0.006156299,0.000009993169],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973395,0.0007631177,0.00036304,0.00008304998,0.00001880275,0.00001842575,0.0004342971,0.00003035578,0.0009494659],"genre_scores_gemma":[0.9966331,0.0006565325,0.00051113,0.00003576731,0.000003380623,0.00002607197,0.0007235469,0.000005396319,0.001405176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001442063,"threshold_uncertainty_score":0.004824221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009779338832163986,"score_gpt":0.2295119202390466,"score_spread":0.2197325814068826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}