{"id":"W1695278265","doi":"10.3109/10799893.2015.1015737","title":"Sigma receptors [<b>σ</b>Rs]: biology in normal and diseased states","year":2015,"lang":"en","type":"article","venue":"Journal of Receptors and Signal Transduction","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":122,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"University of Illinois at Urbana-Champaign","keywords":"Sigma-1 receptor; Receptor; Cell biology; Biology; Signal transduction; Sigma receptor; Biochemistry; Agonist","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002299917,0.0005763164,0.0005607685,0.0006168023,0.000227022,0.0007803478,0.0003437237,0.000858478,0.002372553],"category_scores_gemma":[0.0002769735,0.0001345195,0.0003716146,0.0008568272,0.0003350472,0.0007915926,0.0003275228,0.0007884743,0.001354621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003598249,"about_ca_system_score_gemma":0.0005602914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007249612,"about_ca_topic_score_gemma":0.0008035937,"domain_scores_codex":[0.9998909,0.00002309646,0.0000212397,0.00001919168,0.00002863661,0.00001690331],"domain_scores_gemma":[0.9998788,0.0000309363,0.00002809785,0.000004252713,0.00003370179,0.00002418364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004685173,0.00004627311,0.00111041,0.008703474,0.0001776411,0.001010943,0.0001979794,0.0006356279,0.03198794,0.006437025,0.05841796,0.8908063],"study_design_scores_gemma":[0.00002426486,0.0004211248,0.003097097,0.001183098,0.0001207233,0.003087252,0.0001742727,0.000175395,0.003650114,0.003902492,0.9841312,0.0000330599],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002022188,0.991687,0.001173464,0.001079214,0.0009652709,0.00001093106,0.0001003048,0.00004768468,0.002914065],"genre_scores_gemma":[0.009690415,0.9840973,0.001028231,0.001228104,0.0008827335,0.00002150609,0.0001653654,0.000008785293,0.002877671],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002372553,"threshold_uncertainty_score":0.007937014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01492741863982799,"score_gpt":0.2676790332421973,"score_spread":0.2527516146023693,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}