{"id":"W1699189198","doi":"10.1074/jbc.m115.650531","title":"Distribution and Function of Cardiac Ryanodine Receptor Clusters in Live Ventricular Myocytes","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta","funders":"Canadian Institutes of Health Research; National Heart, Lung, and Blood Institute; Heart and Stroke Foundation of Canada; Centro Nacional de Investigaciones Cardiovasculares; Alberta Innovates; Alberta Innovates - Health Solutions; Ministerio de Ciencia e Innovación","keywords":"Ryanodine receptor 2; Ryanodine receptor; Myocyte; Green fluorescent protein; Immunofluorescence; Biology; Chemistry; Cell biology; Biophysics; Antibody; Intracellular; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001799154,0.0002281505,0.0002799629,0.0003152238,0.0002665079,0.0003890948,0.0004227792,0.0004698878,0.001289705],"category_scores_gemma":[0.0001660834,0.000192347,0.0001949731,0.0002539358,0.0002743267,0.000369112,0.0003763655,0.0004613949,0.0004787337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003600044,"about_ca_system_score_gemma":0.0001402865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004769453,"about_ca_topic_score_gemma":0.0004613274,"domain_scores_codex":[0.99981,0.00001208257,0.00001133741,0.00009040526,0.00004369887,0.00003244391],"domain_scores_gemma":[0.9998647,0.00003413892,0.0000281101,0.00002128546,0.00002283163,0.00002889496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00005657029,0.00001902004,0.0004411648,0.00003239596,0.000006361172,0.00008348221,0.00005994733,0.0001072288,0.997414,0.0001781885,0.00003743628,0.001564251],"study_design_scores_gemma":[0.00006502564,0.0004254641,0.06059124,0.0000456075,0.00006416408,0.001350406,0.0003668678,0.008517154,0.9236837,0.0005977717,0.00426101,0.00003152307],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9685306,0.002252914,0.02467217,0.0001157437,0.00005401366,0.00003944759,0.0007752334,0.0001986655,0.003361182],"genre_scores_gemma":[0.9710358,0.001216701,0.02224499,0.00009659197,0.0000580405,0.0001659353,0.001331045,0.0002071981,0.00364381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001289705,"threshold_uncertainty_score":0.004314482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01445247476782725,"score_gpt":0.2377606444811936,"score_spread":0.2233081697133663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}